SSTR5 and ADCY10

Number of citations of the paper that reports this interaction (PubMedID 9694905)
0

Data Source:
HPRD (in vivo)

		SSTR5	ADCY10
Description		somatostatin receptor 5	adenylate cyclase 10
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Axon Dendrite Growth Cone Motile Cilium Cell Projection Neuronal Cell Body Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Astrocyte End-foot
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding Neuropeptide Binding	Nucleotide Binding Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Lyase Activity Manganese Ion Binding Metal Ion Binding ATPase Binding Bicarbonate Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cytokinesis Somatostatin Signaling Pathway Glucose Homeostasis Regulation Of Insulin Secretion Cellular Response To Glucocorticoid Stimulus	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Glucose Catabolic Process CAMP Biosynthetic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Spermatid Development Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Axon Extension Positive Regulation Of Ossification Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Mitochondrial Depolarization Regulation Of Membrane Repolarization Neuron Projection Retraction Negative Regulation Of Cardiac Muscle Cell Contraction Regulation Of Mitophagy Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Neuron Projection Extension Neuron Projection Maintenance Mitochondrial ATP Transmembrane Transport Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Hedgehog 'off' state
Drugs		Vapreotide Pasireotide Lanreotide Somatostatin Lutetium Lu 177 dotatate Edotreotide gallium Ga-68	Colforsin
Diseases
GWAS		Logical memory (immediate recall) in normal cognition ( 29274321) Polycystic ovary syndrome ( 25574032)
Interacting Genes		9 interacting genes: ADCY10 CNR1 CORT DRD2 GOPC PDZK1 PEX5 SST SSTR1	2 interacting genes: PTGIR SSTR5
Entrez ID		6755	55811
HPRD ID		01677	05549
Ensembl ID		ENSG00000162009	ENSG00000143199
Uniprot IDs		P35346	A0A0K0K1J8 Q96PN6
PDB IDs		8X8L 8X8N 8ZBE 8ZCJ	4CLF 4CLK 4CLL 4CLP 4CLS 4CLT 4CLU 4CLW 4CLY 4CLZ 4CM0 4CM2 4OYA 4OYB 4OYI 4OYM 4OYO 4OYP 4OYW 4OYX 4OYZ 4OZ2 4OZ3 4UST 4USU 4USV 4USW 5D0R 5IV3 5IV4 7OVD 8B75 8CNH 8CO7 8COJ 8COT 8IL7
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Somatostatin Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling GABA-ergic Synapse Regulation Of Monoatomic Anion Transport Positive Regulation Of Developmental Growth Positive Regulation Of Multicellular Organism Growth Signaling Cell-cell Signaling Telencephalon Cell Migration Positive Regulation Of Growth Forebrain Cell Migration Cell Communication G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Developmental Growth Regulation Of Multicellular Organism Growth Bicarbonate Binding Negative Regulation Of Anion Channel Activity Cannabinoid Receptor Activity G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Forebrain Development Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Negative Regulation Of Cardiac Muscle Cell Contraction Neuron Projection Retraction Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Protein Propionyltransferase Activity Axon Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Synapse Regulation Of Monoatomic Ion Transport Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Regulation Of Protein Localization Negative Regulation Of Dopamine Receptor Signaling Pathway Peroxisome Targeting Sequence Binding Central Region Of Growth Cone Hormone Activity Neuromuscular Process Response To Estradiol Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dendrite	Carbohydrate Homeostasis Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Nitric-oxide Synthase Regulator Activity Glucose Homeostasis Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling Cellular Response To Hormone Stimulus TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Positive Regulation Of Cell Cycle Process Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Regulation Of Cell Population Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation G Protein-coupled Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Positive Regulation Of Cell Cycle Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Response To Lipid Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Prostacyclin Receptor Activity G Protein-coupled Receptor Activity Somatostatin Signaling Pathway Somatostatin Receptor Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Maternal Placenta Development
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