SLC9A3 and MAST2

Number of citations of the paper that reports this interaction (PubMedID 16159897)
38

Data Source:
HPRD (in vitro, in vivo)

		SLC9A3	MAST2
Description		solute carrier family 9 member A3	microtubule associated serine/threonine kinase 2
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GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Brush Border Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane
	Molecular Function	Protein Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity PDZ Domain Binding Phosphatidylinositol Binding Identical Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Protein Phosphorylation Cytoskeleton Organization Regulation Of Interleukin-12 Production Intracellular Signal Transduction Spermatid Differentiation
Pathways		Sodium/Proton exchangers
Drugs		Tenapanor
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Estimated glomerular filtration rate ( 31152163) Lung disease severity in cystic fibrosis ( 26417704) Ulcerative colitis ( 23128233 28067908)	Body mass index ( 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Granulocyte count ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 32888494 27863252) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Type 2 diabetes ( 32499647)
Interacting Genes		9 interacting genes: CHP1 CHP2 LRP2 MAST2 NEDD4L NHERF1 NHERF2 PDZK1 SHANK2	27 interacting genes: ACE2 ACTN2 APP CDHR2 DYNLL1 MXRA7 PTEN RPS27A RPS6KA1 SH3GL2 SLC34A1 SLC9A3 SMN1 SNTB2 SRPK2 STK36 SUMO2 TK1 TPM1 TPM2 TPM3 TRAF2 TRAF6 TTN USP7 VANGL2 ZNF417
Entrez ID		6550	23139
HPRD ID		01660	11294
Ensembl ID		ENSG00000066230	ENSG00000086015
Uniprot IDs		P48764	A0A669KBJ4 Q6P0Q8
PDB IDs		7X2U	2KQF 2KYL
Enriched GO Terms of Interacting Partners?		Brush Border Membrane Apical Plasma Membrane Type 2 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 3 Metabotropic Glutamate Receptor Binding Plasma Membrane Phosphatase Binding Regulation Of Sodium Ion Transport Regulation Of Phosphatase Activity Negative Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Import Across Plasma Membrane Regulation Of Dephosphorylation Positive Regulation Of Protein Targeting To Membrane Microvillus Membrane Sodium Ion Transport Protein Localization To Plasma Membrane Regulation Of Protein Targeting To Membrane Intracellular Protein Localization Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Sodium Ion Transmembrane Transport Transmembrane Transport Metal Ion Transport Protein Localization To Cell Periphery Extracellular Exosome Endomembrane System Brush Border Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Monoatomic Cation Transport Protein Localization To Membrane Positive Regulation Of Establishment Of Protein Localization Regulation Of Metal Ion Transport Transport Across Blood-brain Barrier PDZ Domain Binding Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Apical Part Of Cell Regulation Of Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Monoatomic Ion Transport Regulation Of Protein Localization Signaling Receptor Binding Regulation Of Calcium-mediated Signaling Negative Regulation Of Monoatomic Ion Transport Beta-catenin Binding Membrane Folate Transmembrane Transport	Muscle Thin Filament Tropomyosin Identical Protein Binding Structural Constituent Of Muscle Brush Border Membrane Actin Filament Actin Filament Binding Cellular Component Assembly Cytosol Apical Plasma Membrane Sarcomere Organization Enzyme Binding Muscle System Process Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Actin Cytoskeleton CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Negative Regulation Of Smooth Muscle Cell Proliferation Brush Border CD40 Receptor Complex TORC1 Signaling Positive Regulation Of JUN Kinase Activity Organelle Assembly Cytoskeletal Protein Binding Regulation Of Transport Regulation Of Biological Quality Protein Tag Activity Muscle Tissue Morphogenesis Muscle Filament Sliding Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding PDZ Domain Binding TOR Signaling Muscle Contraction Stress Fiber Actin Binding Response To Lead Ion Membrane Raft Postsynaptic Cytoskeleton Organization Presynapse System Process Sodium Ion Import Across Plasma Membrane Cardiac Muscle Hypertrophy Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Protein Metabolic Process Cytoplasmic Side Of Plasma Membrane PML Body
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