SLC9A3 and CHP1

Number of citations of the paper that reports this interaction (PMID 8901634)
31

Data Source:
HPRD (in vitro, in vivo)

		SLC9A3	CHP1
Gene Name		solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	calcineurin-like EF-hand protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Brush Border Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion Microtubule Cytoskeleton Transport Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Sodium:proton Antiporter Activity PDZ Domain Binding	Protein Kinase Inhibitor Activity Transporter Activity Calcium Ion Binding Protein Binding Microtubule Binding Potassium Channel Regulator Activity Kinase Binding Calcium-dependent Protein Binding
	Biological Process	Ion Transport Regulation Of PH Sodium Ion Transmembrane Transport Transmembrane Transport Hydrogen Ion Transmembrane Transport	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Carbohydrate Metabolic Process Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase Mediated Signal Transduction Pathogenesis Negative Regulation Of Phosphatase Activity Calcium Ion-dependent Exocytosis Membrane Docking Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Import Into Nucleus Small Molecule Metabolic Process Transcytosis Protein Stabilization Positive Regulation Of Protein Transport Protein Oligomerization Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane Regulation Of Neuron Death
Pathways		Sodium/Proton exchangers Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Ulcerative colitis ( 23128233)
Protein-Protein Interactions		8 interactors: CHP1 CHP2 LRP2 MAST2 PDZK1 SHANK2 SLC9A3R1 SLC9A3R2	9 interactors: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B
Entrez ID		6550	11261
HPRD ID		01660	06101
Ensembl ID		ENSG00000066230	ENSG00000187446
Uniprot IDs		P48764	H0YKE7 Q99653
PDB IDs			2E30
Enriched GO Terms of Interacting Partners?		Regulation Of Sodium:proton Antiporter Activity Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Proton Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Intracellular Protein Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Transport Regulation Of Sodium Ion Transport Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Intracellular Transport Renal Phosphate Ion Absorption Negative Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatase Activity Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of Dephosphorylation Monocarboxylic Acid Transport Regulation Of Protein Transport Regulation Of Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Monovalent Inorganic Cation Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Protein Glycosylation Regulation Of Protein Import Into Nucleus Positive Regulation Of Transport Regulation Of Signaling Renal Sodium Ion Transport Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Ion Transport Cellular Component Assembly Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Sodium Ion Transmembrane Transport Protein Localization	Regulation Of PH Hydrogen Ion Transmembrane Transport Sodium Ion Transmembrane Transport Proton Transport Sodium Ion Transport Ion Homeostasis Monovalent Inorganic Cation Transport Metal Ion Transport Chemical Homeostasis Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Homeostatic Process Transmembrane Transport Ion Transport Neuron Death Sodium Ion Import Across Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Cell Death Death Sodium Ion Import Cardiac Muscle Cell Contraction Regulation Of The Force Of Heart Contraction By Cardiac Conduction Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of The Force Of Heart Contraction Peptidyl-cysteine S-nitrosylation Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Calcineurin-NFAT Signaling Cascade Pathogenesis Sodium Ion Export Positive Regulation Of NFAT Protein Import Into Nucleus Cellular Response To Acidic PH Positive Regulation Of Action Potential Response To Muscle Stretch Regulation Of Cardiac Muscle Cell Membrane Potential Transport Gastric Acid Secretion Cellular Response To Electrical Stimulus Maintenance Of Cell Polarity Regulation Of Calcineurin-NFAT Signaling Cascade Apoptotic Process Cellular Sodium Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Hyaluronan Catabolic Process Programmed Cell Death Mitochondrion Transport Along Microtubule Cellular Response To PH Positive Regulation Of Sodium Ion Transmembrane Transport Establishment Of Mitochondrion Localization Cellular Response To Epinephrine Stimulus
Tagcloud ?		1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely	antisilencing associating chromodomain clr4 comprise coordinates determinant disrupted dissecting dsr eliminating epe1 facultative fission follows h3k9 heterochromatin machinery mechanistically mei4 meiotic mmi1 participates recruits red1 reversibly ssm4 suv39h transacting
Tagcloud (Difference) ?		1p11 1q42 allows approximate assigned candidate centromere chr chromosomes comparative cytogenetic deduce encoding exchanger expand integrates linkage localizations localized loci map mapping na orient position rat regionally respect unlikely	antisilencing associating chromodomain clr4 comprise coordinates determinant disrupted dissecting dsr eliminating epe1 facultative fission follows h3k9 heterochromatin machinery mechanistically mei4 meiotic mmi1 participates recruits red1 reversibly ssm4 suv39h transacting
Tagcloud (Intersection) ?