NUB1 and SF3B4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NUB1	SF3B4
Description		negative regulator of ubiquitin like proteins 1	splicing factor 3b subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Lewy Body	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding Splicing Factor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Type II Interferon Response To Tumor Necrosis Factor Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly
Pathways			mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Carotid plaque burden ( 28282560) Eyebrow thickness ( 26926045)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth length ( 25281659) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 18391951 20881960 31562340) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		12 interacting genes: AIPL1 COPB1 FANCA NEDD8 PSMD2 PSMD4 SF3B4 SNCAIP UBD UBE2K UFD1 VCP	115 interacting genes: APBB1 BAG3 BAG4 BAIAP2 BMPR1A CD2BP2 CHERP CPSF7 CTTN CWF19L2 DDX17 DDX42 DMRTB1 EEF1A1 EFTUD2 EWSR1 FARSB FKBP1A FRK GRB2 HNRNPD HNRNPF HNRNPH1 HNRNPUL1 HSPB7 ILF3 ITSN1 KHDRBS2 MAPK9 METTL17 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20B MIR21 MIR221 MIR222 MIR25 MIR29A MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-3 MIR9-1 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NCK2 NUB1 OGT PPP1R16B PRPF6 QARS1 RAMAC RBFOX2 RBM10 RBM39 RBM4 RPP25 SEC24D SF1 SF3B2 SFPQ SRSF6 SS18L1 SUMO4 TCAF1 TCERG1 TFG TLE5 TRAF4 UBASH3A WBP4 WDR4 WDR77 WHR1 ZCCHC10 ZNF3 ZNF48
Entrez ID		51667	10262
HPRD ID		07450	12028
Ensembl ID		ENSG00000013374	ENSG00000143368
Uniprot IDs		H3BM14 H3BM74 Q9Y5A7	B3KUJ0 Q15427
PDB IDs		1WJU 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8L 9E8N	1X5T 5GVQ 5Z56 5Z57 5Z58 6AH0 6AHD 6QX9 6Y53 6Y5Q 7ABG 7ABH 7ABI 7DVQ 7EVO 7ONB 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Polyubiquitin Modification-dependent Protein Binding Proteolysis Aggresome Assembly Proteasome Complex Nucleoplasm VCP-NPL4-UFD1 AAA ATPase Complex Inclusion Body Assembly K48-linked Polyubiquitin Modification-dependent Protein Binding Cytosol Cellular Response To Misfolded Protein Proteasome Regulatory Particle, Base Subcomplex Response To Misfolded Protein Ubiquitin Protein Ligase Binding Proteasome Accessory Complex Retrograde Protein Transport, ER To Cytosol Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Protein Metabolic Process Protein Exit From Endoplasmic Reticulum Proteasomal Protein Catabolic Process Interstrand Cross-link Repair Protein Ubiquitination Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Farnesylated Protein Binding Protein Modification By Small Protein Conjugation Proteasome Storage Granule UFD1-NPL4 Complex VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Nucleus Post-translational Protein Modification Regulation Of Protein Catabolic Process Regulation Of Proteolysis ERAD Pathway Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Protein Farnesylation Cytoplasm Protein Quality Control BAT3 Complex Binding Secretory Granule Lumen Endoplasmic Reticulum To Golgi Vesicle-mediated Transport	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Regulation Of MRNA Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of RNA Stability Regulation Of MRNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cytokine Production Negative Regulation Of Protein Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Sprouting Angiogenesis MRNA Processing Negative Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility
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