NUB1

Description		negative regulator of ubiquitin like proteins 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Lewy Body
	Molecular Function	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Type II Interferon Response To Tumor Necrosis Factor Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Carotid plaque burden ( 28282560) Eyebrow thickness ( 26926045)
Interacting Genes		12 interacting genes: AIPL1 COPB1 FANCA NEDD8 PSMD2 PSMD4 SF3B4 SNCAIP UBD UBE2K UFD1 VCP
Entrez ID		51667
HPRD ID		07450
Ensembl ID		ENSG00000013374
Uniprot IDs		H3BM14 H3BM74 Q9Y5A7
PDB IDs		1WJU 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8L 9E8N
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Polyubiquitin Modification-dependent Protein Binding Proteolysis Aggresome Assembly Proteasome Complex Nucleoplasm VCP-NPL4-UFD1 AAA ATPase Complex Inclusion Body Assembly K48-linked Polyubiquitin Modification-dependent Protein Binding Cytosol Cellular Response To Misfolded Protein Proteasome Regulatory Particle, Base Subcomplex Response To Misfolded Protein Ubiquitin Protein Ligase Binding Proteasome Accessory Complex Retrograde Protein Transport, ER To Cytosol Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Protein Metabolic Process Protein Exit From Endoplasmic Reticulum Proteasomal Protein Catabolic Process Interstrand Cross-link Repair Protein Ubiquitination Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Farnesylated Protein Binding Protein Modification By Small Protein Conjugation Proteasome Storage Granule UFD1-NPL4 Complex VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Nucleus Post-translational Protein Modification Regulation Of Protein Catabolic Process Regulation Of Proteolysis ERAD Pathway Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Protein Farnesylation Cytoplasm Protein Quality Control BAT3 Complex Binding Secretory Granule Lumen Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
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