NUB1 and COPB1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NUB1	COPB1
Description		negative regulator of ubiquitin like proteins 1	coat protein complex I subunit beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Lewy Body	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Type II Interferon Response To Tumor Necrosis Factor Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport
Pathways			Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Carotid plaque burden ( 28282560) Eyebrow thickness ( 26926045)	HDL cholesterol ( 26780889) HDL cholesterol levels ( 28334899 32203549) Height ( 31562340) High chromosomal aberration frequency (total) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Vitamin D levels ( 25208829)
Interacting Genes		12 interacting genes: AIPL1 COPB1 FANCA NEDD8 PSMD2 PSMD4 SF3B4 SNCAIP UBD UBE2K UFD1 VCP	46 interacting genes: ADAM19 ANO1 APP ARCN1 ARF1 BCAR1 COPE COPG1 COPG2 DSCR9 ERBIN FOXB1 GORAB GRB2 GTPBP4 HLA-DPB1 HLA-G ID1 IRAK3 KCNK3 KDELR1 KIAA1328 LINC00839 LZTS1 LZTS2 NUB1 PDGFRB PRKCE PTEN RGS2 RGS4 RHOQ RNF10 SERTAD1 SNTA1 SPTBN1 TANK TAPBP TMED10 TRIM37 TTYH2 UBC UBQLN4 VPS18 WBP2 XRCC6
Entrez ID		51667	1315
HPRD ID		07450	02981
Ensembl ID		ENSG00000013374	ENSG00000129083
Uniprot IDs		H3BM14 H3BM74 Q9Y5A7	P53618
PDB IDs		1WJU 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8L 9E8N
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Polyubiquitin Modification-dependent Protein Binding Proteolysis Aggresome Assembly Proteasome Complex Nucleoplasm VCP-NPL4-UFD1 AAA ATPase Complex Inclusion Body Assembly K48-linked Polyubiquitin Modification-dependent Protein Binding Cytosol Cellular Response To Misfolded Protein Proteasome Regulatory Particle, Base Subcomplex Response To Misfolded Protein Ubiquitin Protein Ligase Binding Proteasome Accessory Complex Retrograde Protein Transport, ER To Cytosol Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Protein Metabolic Process Protein Exit From Endoplasmic Reticulum Proteasomal Protein Catabolic Process Interstrand Cross-link Repair Protein Ubiquitination Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Farnesylated Protein Binding Protein Modification By Small Protein Conjugation Proteasome Storage Granule UFD1-NPL4 Complex VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Nucleus Post-translational Protein Modification Regulation Of Protein Catabolic Process Regulation Of Proteolysis ERAD Pathway Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Protein Farnesylation Cytoplasm Protein Quality Control BAT3 Complex Binding Secretory Granule Lumen Endoplasmic Reticulum To Golgi Vesicle-mediated Transport	COPI-coated Vesicle Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum COPI Vesicle Coat COPI-coated Vesicle Transport Vesicle Golgi Vesicle Transport Vesicle-mediated Transport Golgi Membrane Negative Regulation Of Glycine Import Across Plasma Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Establishment Of Protein Localization Positive Regulation Of Reactive Oxygen Species Metabolic Process Golgi Apparatus Regulation Of Actin Cytoskeleton Organization Regulation Of Biological Quality Cytoplasmic Vesicle Regulation Of Actin Filament-based Process Endoplasmic Reticulum-Golgi Intermediate Compartment Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of Cytoskeleton Organization Endoplasmic Reticulum Membrane Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Negative Regulation Of Organ Growth Intra-Golgi Vesicle-mediated Transport Peptide Antigen Binding Regulation Of Protein Metabolic Process Plasma Membrane Regulation Of Innate Immune Response Signaling Receptor Activator Activity Positive Regulation Of Macromolecule Biosynthetic Process Neuron Projection Organization Cytoplasm Positive Regulation Of Metabolic Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cytokine Production Regulation Of Cellular Component Organization Membrane Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process Cellular Localization Regulation Of Intracellular Signal Transduction Intracellular Protein Localization Intracellular Protein Transport ER To Golgi Transport Vesicle Membrane Positive Regulation Of Tolerance Induction
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