CLK1 and BCLAF1

Number of citations of the paper that reports this interaction (PMID 12890497)
11

Data Source:
BioGRID (two hybrid)

		CLK1	BCLAF1
Gene Name		CDC-like kinase 1	BCL2-associated transcription factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity ATP Binding	DNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Cell Proliferation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation	Transcription, DNA-templated Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs		Debromohymenialdisine ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Diseases
GWAS
Protein-Protein Interactions		20 interactors: BCLAF1 GOLM1 KRTAP10-7 LUC7L3 MBP NCOR1 PDE9A PIAS4 PPIG PRMT5 PRPF4 PTPN1 SAFB SRPK1 SRPK2 SRSF1 SRSF3 SRSF6 UBL5 YWHAG	9 interactors: BCL2 BCL2L1 CHD1 CLK1 CSNK2A1 EMD LEMD3 PIN1 YWHAG
Entrez ID		1195	9774
HPRD ID		09058	16544
Ensembl ID		ENSG00000013441	ENSG00000029363
Uniprot IDs		P49759	E9PK91 Q9NYF8
PDB IDs		1Z57 2VAG
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Spliceosomal Complex Assembly Ribonucleoprotein Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecular Complex Assembly Nuclear Export MRNA Transport Nucleus Organization Positive Regulation Of Viral Genome Replication RNA Transport Transcription, DNA-templated RNA Localization RNA Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Viral Genome Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear Speck Organization Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Response To DNA Damage Stimulus Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Cell Death Cellular Metabolic Process Regulation Of Viral Genome Replication	Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Regulation Of Organelle Organization Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Anoikis Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of Anoikis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Cell Cycle Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Mitochondrial Membrane Permeability Mitotic Cell Cycle Process Positive Regulation Of Intracellular Transport Regulation Of Membrane Permeability Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Mitotic Cell Cycle Regulation Of Protein Localization Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peptidyl-threonine Phosphorylation Response To Gamma Radiation Rhythmic Process Membrane Organization Neuron Apoptotic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Skeletal Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Mitochondrial Membrane Organization Neuron Death Ovarian Follicle Development Cellular Response To Organic Substance Apoptotic Process Apoptotic Mitochondrial Changes Organelle Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Programmed Cell Death Regulation Of Cellular Localization Cell Cycle Process Negative Regulation Of Cellular PH Reduction
Tagcloud ?		10q 11q 13q 14q 15q 1q 21q 2q 3p 3q 4q 6q 8q 9q aberration acsl1 ethnicities gains governing incurable karyotypes lyst malaysia malaysian myeloma nfkbia penetrance predispositions xq	abcb7 advance alas2 asxl1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Difference) ?		10q 11q 13q 14q 15q 1q 21q 2q 3p 3q 4q 6q 8q 9q aberration acsl1 ethnicities gains governing incurable karyotypes lyst malaysia malaysian myeloma nfkbia penetrance predispositions xq	abcb7 advance alas2 asxl1 brca1 causal cbl cd34 december deregulation disruption doi erythroid exon hnrnpd leu link online pathophysiology prpf8 publication rars refractory sf3b1 sideroblasts slc25a37 splicing transcript transcriptome
Tagcloud (Intersection) ?