CLK1 and ZRSR2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		CLK1	ZRSR2
Description		CDC like kinase 1	zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex U2AF Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of RNA Splicing	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Minor Pathway
Drugs		Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		170 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP CLK2 COCH CRNKL1 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DDX23 DENND4A DNAJC13 DNAJC24 DOCK9 DPYD DSC2 DVL3 ECE1 ELP6 ENO1 ENTREP2 ERFE FAT1 FBF1 FHIP2B GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-6 KRTAP10-7 LINS1 LMNA LNX1 LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MICU3 MKRN2 MTBP MTCL1 MTPAP MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIGP PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRP4K PRPF38A PRPF4 PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SH2B2 SHROOM1 SLC35D3 SLC75A1 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRRM4 SRSF1 SRSF10 SRSF12 SRSF6 SRSF8 SSBP3 STIP1 STK31 SVOP TDRD9 TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148 ZNF830 ZRSR2	23 interacting genes: APP CCNL1 CLK1 CLK2 DSCR9 DVL3 KHDC4 LUC7L2 PRPF6 REP15 RPS27L SDCBP2 SPATS2L SRPK2 SRRM4 SRSF1 SRSF2 SRSF5 SSX2IP TEPSIN TNFAIP8L1 U2AF1 U2AF2
Entrez ID		1195	8233
HPRD ID		09058	02068
Ensembl ID		ENSG00000013441	ENSG00000169249
Uniprot IDs		P49759	A0A8I5KSD0 Q15696
PDB IDs		1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6QTY 6R3D 6R6E 6R6X 6R8J 6RAA 6TW2 6YTA 6YTD 6YTE 6YTG 6YTI 6Z4Z 6Z50 6ZLN 7AK3 7O9Y 7OA0 7OPG 8P04 8P08 8UWN
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing RNA Metabolic Process RNA Binding Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Catalytic Step 2 Spliceosome Nucleoplasm Nucleic Acid Binding MRNA Splice Site Recognition Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Negative Regulation Of RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RS Domain Binding Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Nuclear Matrix Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Topoisomerase Binding	Regulation Of RNA Splicing Nuclear Speck Protein-RNA Complex Assembly RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Metabolic Process MRNA Splice Site Recognition RNA Binding RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-containing Complex Assembly Spliceosomal Complex Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RNA Splicing, Via Transesterification Reactions MRNA Binding RS Domain Binding Positive Regulation Of RNA Splicing Pre-mRNA 3'-splice Site Binding U2AF Complex Spliceosomal Complex Assembly RNA Metabolic Process Protein Kinase B Binding Cellular Component Assembly MRNA Splicing, Via Spliceosome Nucleus Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein Serine/threonine/tyrosine Kinase Activity Liver Regeneration Neuron Maturation Nucleoplasm Nucleic Acid Binding Nucleic Acid Metabolic Process Frizzled Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glucose Transporter Complex Coated Vesicle Membrane
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