CLK1 and PRDX5

Number of citations of the paper that reports this interaction (PubMedID 26167880)
0

Data Source:
BioGRID (enzymatic study)

		CLK1	PRDX5
Description		CDC like kinase 1	peroxiredoxin 5
Image
GO Annotations	Cellular Component	Nucleus	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Polymerase III Transcription Regulatory Region Sequence-specific DNA Binding Peroxidase Activity Signaling Receptor Binding Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Peroxynitrite Reductase Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Regulation Of RNA Splicing	Inflammatory Response Response To Oxidative Stress Negative Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Oxidoreductase Activity Regulation Of Apoptosis Involved In Tissue Homeostasis Cellular Oxidant Detoxification Reactive Nitrogen Species Metabolic Process
Pathways
Drugs		Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib	Auranofin Diminazene
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	Alopecia areata ( 20596022 25608926) Crohn's disease ( 21102463 28067908) Multiple sclerosis ( 24076602 31604244) Psoriasis ( 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Psoriasis vulgaris ( 26626624) Sarcoidosis ( 22837380) Vitiligo ( 27723757)
Interacting Genes		170 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP CLK2 COCH CRNKL1 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DDX23 DENND4A DNAJC13 DNAJC24 DOCK9 DPYD DSC2 DVL3 ECE1 ELP6 ENO1 ENTREP2 ERFE FAT1 FBF1 FHIP2B GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-6 KRTAP10-7 LINS1 LMNA LNX1 LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MICU3 MKRN2 MTBP MTCL1 MTPAP MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIGP PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRP4K PRPF38A PRPF4 PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SH2B2 SHROOM1 SLC35D3 SLC75A1 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRRM4 SRSF1 SRSF10 SRSF12 SRSF6 SRSF8 SSBP3 STIP1 STK31 SVOP TDRD9 TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148 ZNF830 ZRSR2	10 interacting genes: APP CCDC90B CDKN2D CLK1 ERBB2 ERBB3 ERBB4 NUFIP2 PEX5 SMCP
Entrez ID		1195	25824
HPRD ID		09058	05958
Ensembl ID		ENSG00000013441	ENSG00000126432
Uniprot IDs		P49759	P30044
PDB IDs		1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6QTY 6R3D 6R6E 6R6X 6R8J 6RAA 6TW2 6YTA 6YTD 6YTE 6YTG 6YTI 6Z4Z 6Z50 6ZLN 7AK3 7O9Y 7OA0 7OPG 8P04 8P08 8UWN	1H4O 1HD2 1OC3 1URM 2VL2 2VL3 2VL9 3MNG 4K7I 4K7N 4K7O 4MMM
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing RNA Metabolic Process RNA Binding Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Catalytic Step 2 Spliceosome Nucleoplasm Nucleic Acid Binding MRNA Splice Site Recognition Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Negative Regulation Of RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RS Domain Binding Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Nuclear Matrix Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Topoisomerase Binding	ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Neuregulin Receptor Activity Receptor Complex ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Glial Cell Development Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Growth ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Neuron Differentiation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade Peripheral Nervous System Development Protein Kinase Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Forebrain Neuron Differentiation Regulation Of MAPK Cascade Synapse Organization Kinase Activity Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Growth Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Basolateral Plasma Membrane Heart Development Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Regulation Of ERK1 And ERK2 Cascade Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Localization To Synapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?