IL23A and PEX19

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		IL23A	PEX19
Gene Name		interleukin 23, alpha subunit p19	peroxisomal biogenesis factor 19
Image
Gene Ontology Annotations	Cellular Component	Interleukin-23 Complex	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Integral Component Of Membrane Brush Border Membrane Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Cytokine Activity Protein Binding Interleukin-23 Receptor Binding	Protein Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-terminus Binding ATPase Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of JAK2 Kinase Activity Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Remodeling Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Protein Targeting To Peroxisome Peroxisome Organization Peroxisome Membrane Biogenesis Peroxisome Fission Protein Import Into Peroxisome Membrane Protein Stabilization Transmembrane Transport Chaperone-mediated Protein Folding Chaperone-mediated Protein Transport Establishment Of Protein Localization To Peroxisome Negative Regulation Of Lipid Binding
Pathways			ABC-family proteins mediated transport ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS		Psoriasis ( 20953190 19169254)
Protein-Protein Interactions		3 interactors: IL12RB1 IL23R PEX19	32 interactors: ABCD1 ABCD2 ABCD3 CDC25A CDKN2A EIF1B F11R FKBP7 GSKIP IL23A IRF3 KIFAP3 MFSD5 OIP5 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX26 PEX3 PMP22 PPIB PXMP4 SLC25A17 SLC34A1 SMAD2 SRPK1 STK3 TMEM54
Entrez ID		51561	5824
HPRD ID		12026	02610
Ensembl ID		ENSG00000110944	ENSG00000162735
Uniprot IDs		Q9NPF7	P40855
PDB IDs		3D85 3D87 3DUH 3QWR	2W85 2WL8 3AJB 3MK4
Enriched GO Terms of Interacting Partners?		Interleukin-23-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Cell Fate Commitment Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Regulation Of Defense Response To Virus By Host Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Interferon-gamma Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Interferon-gamma Production Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of T Cell Proliferation Positive Regulation Of Adaptive Immune Response Negative Regulation Of Lipid Binding Regulation Of Lymphocyte Differentiation Response To Interferon-gamma Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Interleukin-12-mediated Signaling Pathway Regulation Of T Cell Activation Peroxisome Membrane Biogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Cell Activation Positive Regulation Of NK T Cell Activation Response To Interleukin-12 Positive Regulation Of Activation Of JAK2 Kinase Activity	Peroxisome Organization Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Peroxisomal Membrane Transport Protein Import Peroxisome Membrane Biogenesis Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Protein Import Into Peroxisome Membrane Organelle Organization Protein To Membrane Docking Transmembrane Transport Establishment Of Protein Localization To Organelle Fatty Acid Beta-oxidation Protein Targeting Cellular Lipid Catabolic Process Protein Localization To Organelle Regulation Of Peroxisome Size Lipid Modification Membrane Biogenesis Carboxylic Acid Catabolic Process Protein Import Into Peroxisome Matrix, Docking Very Long-chain Fatty Acid Metabolic Process Lipid Catabolic Process Cytoplasmic Transport Fatty Acid Alpha-oxidation Fatty Acid Metabolic Process Establishment Of Protein Localization Peroxisome Fission Intracellular Transport Protein Localization Cellular Localization Intracellular Protein Transport Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Membrane Cellular Protein Localization Protein Stabilization Membrane Docking Posttranscriptional Regulation Of Gene Expression Protein Transport Positive Regulation Of Viral Genome Replication Cellular Component Assembly Regulation Of Defense Response To Virus By Host Monocarboxylic Acid Metabolic Process
Tagcloud ?		acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il15ra il1a il1b il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7	amphipathic anchored biogenesis chaperone concerted delivers docking engagement hydrophobic hydrophobicity inserted insertion intercalation moieties peroxisome pex3 promotes prompt reconstitute segment segments sequential steps ta tail tmd translationally uncharacterized unconventional
Tagcloud (Difference) ?		acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il15ra il1a il1b il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7	amphipathic anchored biogenesis chaperone concerted delivers docking engagement hydrophobic hydrophobicity inserted insertion intercalation moieties peroxisome pex3 promotes prompt reconstitute segment segments sequential steps ta tail tmd translationally uncharacterized unconventional
Tagcloud (Intersection) ?