IL23A and IL23R

Number of citations of the paper that reports this interaction (PMID 12023369)
206

Data Source:
HPRD (in vivo, in vitro)

		IL23A	IL23R
Gene Name		interleukin 23, alpha subunit p19	interleukin 23 receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Interleukin-23 Complex	Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Interleukin-23 Receptor Binding	Interleukin-12 Receptor Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of JAK2 Kinase Activity Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Remodeling Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of JAK2 Kinase Activity Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Interferon-gamma Interleukin-23-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways
Drugs
Diseases
GWAS		Psoriasis ( 20953190 19169254)	Ankylosing spondylitis ( 21743469 20062062) Behcet's disease ( 20622878 20622879) Crohn's disease ( 18587394 20570966 22936669 22412388 17435756 17554300 21102463 17447842 22293688 17804789) Inflammatory bowel disease ( 18758464 23128233 17068223) Leprosy ( 22019778) Psoriasis ( 20953190 19169254) Ulcerative colitis ( 19915572 20228799 21297633 19122664)
Protein-Protein Interactions		3 interactors: IL12RB1 IL23R PEX19	5 interactors: C1D IL12RB1 IL23A JAK2 STAT3
Entrez ID		51561	149233
HPRD ID		12026	16249
Ensembl ID		ENSG00000110944	ENSG00000162594
Uniprot IDs		Q9NPF7	Q5VWK5
PDB IDs		3D85 3D87 3DUH 3QWR
Enriched GO Terms of Interacting Partners?		Interleukin-23-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Cell Fate Commitment Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Regulation Of Defense Response To Virus By Host Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Interferon-gamma Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Interferon-gamma Production Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of T Cell Proliferation Positive Regulation Of Adaptive Immune Response Negative Regulation Of Lipid Binding Regulation Of Lymphocyte Differentiation Response To Interferon-gamma Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Interleukin-12-mediated Signaling Pathway Regulation Of T Cell Activation Peroxisome Membrane Biogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Cell Activation Positive Regulation Of NK T Cell Activation Response To Interleukin-12 Positive Regulation Of Activation Of JAK2 Kinase Activity	Interleukin-12-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Interferon-gamma Production JAK-STAT Cascade Defense Response Positive Regulation Of Tumor Necrosis Factor Production Cytokine-mediated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Interferon-gamma Production Regulation Of T Cell Mediated Cytotoxicity Cellular Response To Cytokine Stimulus Regulation Of JAK-STAT Cascade Regulation Of Cell Migration
Tagcloud ?		acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il15ra il1a il1b il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7	1p36 21q21 bowel c13orf31 colitis crohn danish epistasis epistatic il10 latvia latvian lithuania lithuanian maps mst1 nkx2 northeastern ormdl3 ptpn22 rs2476601 rs3764147 snp snps strongest subphenotype tagging uc ulcerative
Tagcloud (Difference) ?		acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il15ra il1a il1b il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7	1p36 21q21 bowel c13orf31 colitis crohn danish epistasis epistatic il10 latvia latvian lithuania lithuanian maps mst1 nkx2 northeastern ormdl3 ptpn22 rs2476601 rs3764147 snp snps strongest subphenotype tagging uc ulcerative
Tagcloud (Intersection) ?