IL23A and IL23R

Number of citations of the paper that reports this interaction (PubMedID 12023369)
0

Data Source:
HPRD (in vitro, in vivo)

		IL23A	IL23R
Description		interleukin 23 subunit alpha	interleukin 23 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-23 Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Interleukin-23 Receptor Binding	Cytokine Receptor Activity Prolactin Receptor Activity Interleukin-12 Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation Tissue Remodeling Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Regulation Of Primary Metabolic Process Positive Regulation Of Neutrophil Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Leukocyte Differentiation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Type II Interferon Interleukin-23-mediated Signaling Pathway Prolactin Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs		Briakinumab Ustekinumab Guselkumab Tildrakizumab Risankizumab
Diseases			Crohn's disease
GWAS		Axial length ( 24144296) Psoriasis ( 19169254 20953190 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 21743469 23749187 20062062) Behcet's disease ( 33393726 20622879 20622878) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23850713 28067908 22936669 30500874 32581322 22412388 22293688 17447842 17435756 21102463 17554300 20570966 17804789 18587394) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233 28067908 18758464 28008999) Inflammatory skin disease ( 25574825) Leprosy ( 22019778 25642632) Pediatric autoimmune diseases ( 26301688) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Psoriasis ( 25903422 20953190 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Sarcoidosis ( 26051272 32826979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 19122664 19915572 28067908 20228799 26398853 32072174 21297633) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		3 interacting genes: IL12RB1 IL23R PEX19	5 interacting genes: C1D IL12RB1 IL23A JAK2 STAT3
Entrez ID		51561	149233
HPRD ID		12026	16249
Ensembl ID		ENSG00000110944	ENSG00000162594
Uniprot IDs		Q9NPF7	Q5VWK5
PDB IDs		3D85 3D87 3DUH 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD 6UIB 6WDQ 8CR8 8OE4	5MZV 6WDQ 8OE4
Enriched GO Terms of Interacting Partners?		Interleukin-23 Binding Interleukin-23 Receptor Activity Interleukin-23 Receptor Complex Interleukin-12 Receptor Binding Interleukin-23-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Memory T Cell Differentiation Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Activated T Cell Proliferation Cytokine Binding Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Defense Response To Virus Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Response To Type II Interferon Regulation Of T Cell Mediated Immunity Positive Regulation Of T Cell Proliferation Interleukin-12 Receptor Activity Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Regulation Of Type II Interferon Production Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation	Interleukin-23-mediated Signaling Pathway Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of T-helper 17 Type Immune Response Interleukin-12 Receptor Complex Positive Regulation Of Skeletal Muscle Cell Proliferation Interleukin-23 Receptor Complex Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Type II Interferon Production Interleukin-12 Receptor Binding Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T Cell Proliferation Interleukin-12-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of NK T Cell Activation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Type II Interferon Production Positive Regulation Of Cytokine Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Cell Fate Commitment Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Skeletal Muscle Cell Proliferation T-helper 1 Cell Differentiation Interleukin-6-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of T-helper 1 Type Immune Response Regulation Of Tumor Necrosis Factor Production Regulation Of T Cell Proliferation Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Growth Hormone Receptor Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Adaptive Immune Response Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-17 Production
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