IL23A

Description		interleukin 23 subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-23 Complex
	Molecular Function	Cytokine Activity Protein Binding Interleukin-23 Receptor Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation Tissue Remodeling Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Regulation Of Primary Metabolic Process Positive Regulation Of Neutrophil Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Leukocyte Differentiation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs		Briakinumab Ustekinumab Guselkumab Tildrakizumab Risankizumab
Diseases
GWAS		Axial length ( 24144296) Psoriasis ( 19169254 20953190 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: NEUROD4
Interacting Genes		3 interacting genes: IL12RB1 IL23R PEX19
Entrez ID		51561
HPRD ID		12026
Ensembl ID		ENSG00000110944
Uniprot IDs		Q9NPF7
PDB IDs		3D85 3D87 3DUH 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD 6UIB 6WDQ 8CR8 8OE4
Enriched GO Terms of Interacting Partners?		Interleukin-23 Binding Interleukin-23 Receptor Activity Interleukin-23 Receptor Complex Interleukin-12 Receptor Binding Interleukin-23-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Memory T Cell Differentiation Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Activated T Cell Proliferation Cytokine Binding Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Defense Response To Virus Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Response To Type II Interferon Regulation Of T Cell Mediated Immunity Positive Regulation Of T Cell Proliferation Interleukin-12 Receptor Activity Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Regulation Of Type II Interferon Production Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation
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