SPG21 and ATPAF2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPG21	ATPAF2
Gene Name		spastic paraplegia 21 (autosomal recessive, Mast syndrome)	ATP synthase mitochondrial F1 complex assembly factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle	Mitochondrion Nuclear Speck
	Molecular Function	Protein Binding CD4 Receptor Binding	Protein Binding
	Biological Process	Antigen Receptor-mediated Signaling Pathway	Proton-transporting ATP Synthase Complex Assembly
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: AGTRAP AKIRIN2 ARL6IP1 ATPAF2 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263	23 interactors: APP ATP5A1 ATP5B DDIT3 EBF1 EWSR1 IKZF3 KRT40 LNX1 LRRFIP2 LZTS2 MAGEA6 PAK7 PKP4 PRDM14 RAD54B REL RPIA SORBS2 SPG21 TP53BP2 TRIM23 TRIM27
Entrez ID		51324	91647
HPRD ID		10492	10599
Ensembl ID		ENSG00000090487	ENSG00000171953
Uniprot IDs		Q9NZD8	Q8N5M1
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Ubiquitination Regulation Of Cell Death Protein Modification By Small Protein Conjugation Negative Regulation Of Developmental Growth Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Death Immune Response Negative Regulation Of Organ Growth Negative Regulation Of UDP-glucose Catabolic Process Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Localization Negative Regulation Of Muscle Organ Development Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Pyrimidine Nucleotide Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of SNARE Complex Assembly Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Urate Biosynthetic Process 'de Novo' CTP Biosynthetic Process Glycogen Metabolic Process Regulation Of Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Differentiation Positive Regulation Of Protein Binding Regulation Of Skeletal Muscle Tissue Development Regulation Of Cellular Ketone Metabolic Process Gliogenesis Negative Regulation Of Growth Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process	Mitochondrial ATP Synthesis Coupled Proton Transport Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process ATP Synthesis Coupled Proton Transport Cellular Nitrogen Compound Metabolic Process ATP Biosynthetic Process Negative Regulation Of Determination Of Dorsal Identity Histone H3-R26 Methylation Inner Cell Mass Cell Fate Commitment Nitrogen Compound Metabolic Process ATP Hydrolysis Coupled Proton Transport Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Regulation Of Transcription Involved In Anterior/posterior Axis Specification Intracellular Transport Wnt Signaling Pathway Purine Ribonucleoside Monophosphate Biosynthetic Process Regulation Of Signal Transduction Collateral Sprouting In Absence Of Injury Nucleoside Triphosphate Biosynthetic Process Ribose Phosphate Metabolic Process Transcription, DNA-templated Ribonucleoside Monophosphate Biosynthetic Process Pentose-phosphate Shunt, Non-oxidative Branch
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