ATPAF2 and RPIA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		ATPAF2	RPIA
Description		ATP synthase mitochondrial F1 complex assembly factor 2	ribose 5-phosphate isomerase A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Nuclear Speck	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Ribose-5-phosphate Isomerase Activity Protein Binding Isomerase Activity Carbohydrate Binding Identical Protein Binding Monosaccharide Binding
	Biological Process	Mitochondrial Proton-transporting ATP Synthase Complex Assembly Proton-transporting ATP Synthase Complex Assembly	D-ribose Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch
Pathways			RPIA deficiency: failed conversion of R5P to RU5P RPIA deficiency: failed conversion of RU5P to R5P Pentose phosphate pathway
Drugs			4-phospho-L-threonic acid
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 28991256 29483656) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576)
Interacting Genes		72 interacting genes: AKAP8L APP ATP5F1A ATP5F1B BEGAIN CDC14A CDK2AP1 CEP57 CFAP206 CFAP68 CIMIP2B CRTC2 CTIF CYSRT1 DDIT3 DLGAP4 EBF1 EBF3 EIF4G1 EWSR1 FCHSD2 FNTB GOLGA6L9 IKZF3 INCA1 KRT34 KRT40 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-2 KRTAP6-3 LGALS9B LNX1 LRRFIP2 LURAP1L LZTS2 MAGEA6 MEDAG MIF4GD NME4 PAK5 PKP4 POLR2J3 POLR3F POLR3H PPP1R16B PRDM14 PRDM6 RAD54B RBM48 RCN1 REL RPH3AL RPIA SAXO4 SORBS2 SPATC1L TCHP TFIP11 TP53BP2 TRIM23 TRIM27 UBAP2 VWC2 WASHC1 ZFP90 ZNF19 ZNF23 ZNF35 ZNF426 ZNF655	20 interacting genes: ATPAF2 C14orf119 CENPP DDIT4L FOXP2 FXR1 FXR2 GORASP2 HSPB8 LNX1 NIF3L1 NTAQ1 PCMT1 PICK1 PTPN11 RNF208 SDCBP STK16 TXN2 VTA1
Entrez ID		91647	22934
HPRD ID		10599	01589
Ensembl ID		ENSG00000171953	ENSG00000153574
Uniprot IDs		Q8N5M1	P49247
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Intermediate Filament	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity
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