CDK16 and PJA1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
0

Data Source:
BioGRID (enzymatic study)

		CDK16	PJA1
Description		cyclin dependent kinase 16	praja ring finger ubiquitin ligase 1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Membrane Transport Vesicle Cytoplasmic Vesicle Neuron Projection Synapse	Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Exocytosis Spermatogenesis Positive Regulation Of Autophagy Cell Differentiation Growth Hormone Secretion Neuron Projection Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cell Cycle Phase Transition	Protein Ubiquitination Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs		(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS			Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		20 interacting genes: APP APPBP2 ATRIP BAG6 CCND3 CDK5 CDK5R1 MAGI3 PJA1 PRKACA S100A10 SEC23A SIRPA SNX27 YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14	63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		5127	64219
HPRD ID		02409	02335
Ensembl ID		ENSG00000102225	ENSG00000181191
Uniprot IDs		A0A140VK97 Q00536 Q9BRL4	Q8NG27
PDB IDs		3MTL 5G6V	2L0B
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Domain Specific Binding Transmembrane Transporter Binding Acetylcholine Receptor Activator Activity Intracellular Protein Localization Cellular Localization Protein Targeting Protein Kinase 5 Complex Intracellular Signal Transduction Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Neuron Recognition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Sequestering Activity Phosphoserine Residue Binding Substantia Nigra Development Localization Within Membrane Establishment Of Localization In Cell Intracellular Protein Transport Positive Regulation Of Establishment Of Protein Localization Intracellular Transport Negative Regulation Of Macromolecule Metabolic Process Extracellular Exosome Regulation Of Protein Localization Protein Catabolic Process TORC1 Signaling Neural Nucleus Development Regulation Of Proteolysis Regulation Of Neuron Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Hippocampus Development Regulation Of Synaptic Plasticity Negative Regulation Of Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of Monoatomic Ion Transport Neuromuscular Junction Macromolecule Catabolic Process TOR Signaling Presynapse Regulation Of Developmental Process Negative Regulation Of TOR Signaling Insulin-like Growth Factor Receptor Binding Signal Transduction Proteasomal Protein Catabolic Process Protein Phosphatase Binding	Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator
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