CDK16 and CDK5R1

Number of citations of the paper that reports this interaction (PMID 12084709)
11

Data Source:
HPRD (in vivo, in vitro)

		CDK16	CDK5R1
Gene Name		cyclin-dependent kinase 16	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Synaptic Vesicle Microtubule Cytoskeleton Cell Junction Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Cyclin-dependent Protein Kinase 5 Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding
	Biological Process	Protein Phosphorylation Exocytosis Spermatogenesis Growth Hormone Secretion Neuron Projection Development Regulation Of Cell Cycle Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Neuron Cell-cell Adhesion G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Cell Proliferation Embryo Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Serine Phosphorylation Of STAT3 Protein Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Targeting To Membrane
Pathways			Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP APPBP2 ATRIP BAG6 BRCA1 CDK5 CDK5R1 PRKACA S100A10 SEC23A YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14	31 interactors: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NL ODF1 PAK1 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		5127	8851
HPRD ID		02409	04586
Ensembl ID		ENSG00000102225	ENSG00000176749
Uniprot IDs		B7Z8T0 Q00536 Q9BRL4	Q15078 Q8N619
PDB IDs		3MTL	1H4L 1UNG 1UNH 1UNL 3O0G
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Organelle Organization Apoptotic Process Programmed Cell Death Regulation Of Intracellular Transport Cell Death Death Positive Regulation Of Mitochondrion Organization Regulation Of Organelle Organization Cellular Protein Localization Regulation Of Mitochondrion Organization Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Establishment Of Protein Localization Regulation Of Cell Death Positive Regulation Of Transport Regulation Of Protein Localization Cellular Localization Intracellular Protein Transport Neural Nucleus Development Positive Regulation Of Apoptotic Process Protein Localization Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Cell Death Regulation Of Cellular Localization Intracellular Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Brain Development Regulation Of Signaling Negative Regulation Of Cellular Protein Metabolic Process Head Development Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Metabolic Process Protein Transport Establishment Of Localization In Cell Central Nervous System Development Substantia Nigra Development Peptidyl-threonine Phosphorylation Serine Phosphorylation Of STAT3 Protein Nervous System Development Transport	Generation Of Neurons Nervous System Development Neurogenesis Establishment Of Localization In Cell Neuron Projection Development Cellular Localization Neuron Differentiation Cell Differentiation Cell Projection Organization Neuron Development Multicellular Organismal Development Vesicle-mediated Transport Regulation Of Organelle Organization Regulation Of Neurogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Organization Developmental Process Cell Morphogenesis Involved In Differentiation Exocytosis Axonogenesis Synaptic Vesicle Transport Regulation Of Neuron Differentiation Cell Morphogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Cell Development Regulation Of Cell Development System Development Cell Part Morphogenesis Organelle Localization Neuron Projection Morphogenesis Receptor Catabolic Process Anatomical Structure Development Synapse Organization Regulation Of Cytoskeleton Organization Secretion By Cell Brain Development Receptor Metabolic Process Response To Abiotic Stimulus Head Development Establishment Of Vesicle Localization Negative Regulation Of Neuron Death Vesicle Localization Axon Guidance Regulation Of Cell Differentiation Secretion Anatomical Structure Morphogenesis Regulation Of Cell Cycle Locomotion
Tagcloud ?		analyze animal ccnd1 ccni ccni2 cdk18 cdk3 cdk4 cdk8 cdk9 cdkis cdkn1a cdkn2a cdks comprehensive confirm cyclin database diabetic diagram islets microarray pancreatic pattern qrt reproduce snps t2d	10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?		analyze animal ccnd1 ccni ccni2 cdk18 cdk3 cdk4 cdk8 cdk9 cdkis cdkn1a cdkn2a cdks comprehensive confirm cyclin database diabetic diagram islets microarray pancreatic pattern qrt reproduce snps t2d	10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?