CDK16 and BAG6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		CDK16	BAG6
Description		cyclin dependent kinase 16	BAG cochaperone 6
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Cytosol Plasma Membrane Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Membrane Transport Vesicle Cytoplasmic Vesicle Neuron Projection Synapse	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Extracellular Exosome BAT3 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Signaling Receptor Binding Protein Binding Hsp70 Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ribosome Binding Receptor Ligand Activity Misfolded Protein Binding Molecular Adaptor Activity Proteasome Binding Protein Carrier Chaperone Ubiquitin-specific Protease Binding
	Biological Process	Protein Phosphorylation Exocytosis Spermatogenesis Positive Regulation Of Autophagy Cell Differentiation Growth Hormone Secretion Neuron Projection Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Cell Cycle Phase Transition	Kidney Development Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Maintenance Of Unfolded Protein Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization NK T Cell Activation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS			A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		20 interacting genes: APP APPBP2 ATRIP BAG6 CCND3 CDK5 CDK5R1 MAGI3 PJA1 PRKACA S100A10 SEC23A SIRPA SNX27 YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB14	120 interacting genes: ACVR1B AKT1 AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M BCL2 C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CEBPA CHN2 CILK1 CLU CRIPTO CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT DRC9 EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT KLHL12 KPNA2 LBP MAP1LC3B MAPK6 MECOM MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL7 UBQLN1 UBQLN2 UBQLN4 VAMP2 XRN1 ZFYVE9
Entrez ID		5127	7917
HPRD ID		02409	00808
Ensembl ID		ENSG00000102225	ENSG00000204463
Uniprot IDs		A0A140VK97 Q00536 Q9BRL4	A0A1U9X7A6 A0A7P0MQS5 P46379
PDB IDs		3MTL 5G6V	1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8 7RU9 7RUA 7RUC
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Domain Specific Binding Transmembrane Transporter Binding Acetylcholine Receptor Activator Activity Intracellular Protein Localization Cellular Localization Protein Targeting Protein Kinase 5 Complex Intracellular Signal Transduction Regulation Of Protein Export From Nucleus Regulation Of Synapse Organization Neuron Recognition Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Sequestering Activity Phosphoserine Residue Binding Substantia Nigra Development Localization Within Membrane Establishment Of Localization In Cell Intracellular Protein Transport Positive Regulation Of Establishment Of Protein Localization Intracellular Transport Negative Regulation Of Macromolecule Metabolic Process Extracellular Exosome Regulation Of Protein Localization Protein Catabolic Process TORC1 Signaling Neural Nucleus Development Regulation Of Proteolysis Regulation Of Neuron Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Negative Regulation Of TORC1 Signaling Positive Regulation Of Neuron Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Hippocampus Development Regulation Of Synaptic Plasticity Negative Regulation Of Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of Monoatomic Ion Transport Neuromuscular Junction Macromolecule Catabolic Process TOR Signaling Presynapse Regulation Of Developmental Process Negative Regulation Of TOR Signaling Insulin-like Growth Factor Receptor Binding Signal Transduction Proteasomal Protein Catabolic Process Protein Phosphatase Binding	Regulation Of Cellular Response To Stress Extracellular Space Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Extracellular Region Protein Binding Membrane Organization Receptor Ligand Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Endoplasmic Reticulum Stress Signal Transduction Response To Hormone Negative Regulation Of Proteolysis Extracellular Matrix Negative Regulation Of Cellular Component Organization Response To Lipid Tissue Development Regulation Of Protein Catabolic Process Tau Protein Binding Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Leukocyte Apoptotic Process Positive Regulation Of Neutrophil Chemotaxis Regulation Of Ossification G1/S Transition Of Mitotic Cell Cycle Protein-containing Complex Establishment Of Protein Localization To Organelle Molecular Function Activator Activity Cell Cycle G1/S Phase Transition Negative Regulation Of Developmental Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Multicellular Organismal Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Migration Regulation Of Developmental Process Response To Nutrient Levels Cellular Response To Oxygen-containing Compound Endoplasmic Reticulum Lumen T Cell Apoptotic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction
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