LEF1 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		LEF1	MLH3
Description		lymphoid enhancer binding factor 1	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Beta-catenin-TCF Complex	Condensed Chromosome Condensed Nuclear Chromosome Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding DNA Binding, Bending Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding C2H2 Zinc Finger Domain Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation Somitogenesis Epithelial To Mesenchymal Transition Vasculature Development Sprouting Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Dentate Gyrus Development Hippocampus Development Forebrain Radial Glial Cell Differentiation Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Regulation Of Cell-cell Adhesion Regulation Of Wnt Signaling Pathway Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Neutrophil Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Granulocyte Differentiation Mammary Gland Development Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production T Cell Receptor V(D)J Recombination B Cell Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Tongue Development Host-mediated Activation Of Viral Transcription T-helper 1 Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Paraxial Mesoderm Formation Cell Development Regulation Of Neurogenesis Sensory Perception Of Taste Anatomical Structure Regression Canonical Wnt Signaling Pathway Face Morphogenesis Cell Chemotaxis Apoptotic Process Involved In Morphogenesis Chorio-allantoic Fusion Trachea Gland Development Secondary Palate Development Protein Localization To Chromatin Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Cycle Process Positive Regulation Of Odontoblast Differentiation Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Chondrocyte Proliferation Epithelial Cell Apoptotic Process Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin	DNA Repair Mismatch Repair DNA Damage Response Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Intracellular Protein Localization
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Cardiogenesis Germ layer formation at gastrulation Formation of paraxial mesoderm Formation of axial mesoderm Somitogenesis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription	Meiotic recombination
Drugs		Etacrynic acid
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Airflow obstruction ( 22837378) Blond vs. brown/black hair color ( 30531825) Chronic lymphocytic leukemia ( 23770605 26956414 28165464) Diastolic blood pressure ( 27841878) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 19060910) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 22291604) Systolic blood pressure ( 27841878 30578418) Tooth agenesis (mandibular second premolars) ( 29364747)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		34 interacting genes: ALX4 ALYREF AURKA BAX BUB1 CDX1 CTNNB1 DPYSL2 EP300 KPNA1 KPNA2 MITF MLH1 MLH3 MSH2 NFE2L2 NLK NOTCH1 NRAS PIAS4 PITX2 RB1 RUNX2 SMAD1 SMAD2 SMAD3 SMAD4 STK11 SUMO2 TLE1 TLE2 TRA UBTF ZBTB3	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		51176	27030
HPRD ID		01075	05094
Ensembl ID		ENSG00000138795	ENSG00000119684
Uniprot IDs		Q9UJU2	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process I-SMAD Binding Axis Specification Animal Organ Morphogenesis Pattern Specification Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Tube Development SMAD Protein Complex Positive Regulation Of Metabolic Process Heteromeric SMAD Protein Complex Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of RNA Metabolic Process Cell Fate Commitment Embryonic Pattern Specification Regionalization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation Regulation Of Wnt Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Anterior/posterior Pattern Specification Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Developmental Growth Regulation Of Metabolic Process Wnt Signaling Pathway Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Mismatch Repair Fructose 1,6-bisphosphate Metabolic Process Mismatched DNA Binding Fructose Metabolic Process Canonical Wnt Signaling Pathway Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Reproductive Process Gluconeogenesis Carbohydrate Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Hexose Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Deoxyribonuclease Activity Regulation Of Protein Localization To Synapse Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Cell Periphery Insulin-like Growth Factor Receptor Signaling Pathway Enzyme Binding Regulation Of Protein Localization To Membrane Negative Regulation Of Phosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process DNA Repair Cellular Response To Radiation Positive Regulation Of Isotype Switching To IgA Isotypes Cell Population Proliferation DNA Metabolic Process Small Molecule Biosynthetic Process Neural Tube Development Cellular Response To Stress Somatic Cell DNA Recombination Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Ras Protein Signal Transduction Response To Steroid Hormone Response To Ketone Meiotic Cell Cycle Tube Development Male Germ Cell Nucleus Negative Regulation Of Striated Muscle Tissue Development Glucose Metabolic Process Osteoblast Differentiation Response To Stress Regulation Of Generation Of Precursor Metabolites And Energy Response To Oxidative Stress Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription MAPK Cascade Animal Organ Regeneration
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