LEF1 and NFE2L2

Number of citations of the paper that reports this interaction (PubMedID 32911434)
54

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LEF1	NFE2L2
Description		lymphoid enhancer binding factor 1	NFE2 like bZIP transcription factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Beta-catenin-TCF Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Mediator Complex Protein-DNA Complex Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding DNA Binding, Bending Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding C2H2 Zinc Finger Domain Binding Transcription Regulator Inhibitor Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation Somitogenesis Epithelial To Mesenchymal Transition Vasculature Development Sprouting Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Dentate Gyrus Development Hippocampus Development Forebrain Radial Glial Cell Differentiation Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Regulation Of Cell-cell Adhesion Regulation Of Wnt Signaling Pathway Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Neutrophil Differentiation Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of Granulocyte Differentiation Mammary Gland Development Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production T Cell Receptor V(D)J Recombination B Cell Proliferation Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Tongue Development Host-mediated Activation Of Viral Transcription T-helper 1 Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Paraxial Mesoderm Formation Cell Development Regulation Of Neurogenesis Sensory Perception Of Taste Anatomical Structure Regression Canonical Wnt Signaling Pathway Face Morphogenesis Cell Chemotaxis Apoptotic Process Involved In Morphogenesis Chorio-allantoic Fusion Trachea Gland Development Secondary Palate Development Protein Localization To Chromatin Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-4 Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Cycle Process Positive Regulation Of Odontoblast Differentiation Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Chondrocyte Proliferation Epithelial Cell Apoptotic Process Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin	Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Gene Expression Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Innate Immune Response Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of D-glucose Import Cellular Response To Methionine Response To Caloric Restriction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of Ferroptosis Integrated Stress Response Signaling Negative Regulation Of Cellular Response To Hypoxia Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of ERAD Pathway Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Cardiogenesis Germ layer formation at gastrulation Formation of paraxial mesoderm Formation of axial mesoderm Somitogenesis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription	Neddylation Potential therapeutics for SARS Regulation of HMOX1 expression and activity Heme signaling KEAP1-NFE2L2 pathway KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 NFE2L2 regulating TCA cycle genes NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription
Drugs		Etacrynic acid
Diseases
GWAS		Airflow obstruction ( 22837378) Blond vs. brown/black hair color ( 30531825) Chronic lymphocytic leukemia ( 23770605 26956414 28165464) Diastolic blood pressure ( 27841878) Medication use (calcium channel blockers) ( 31015401) Metabolic traits ( 19060910) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 22291604) Systolic blood pressure ( 27841878 30578418) Tooth agenesis (mandibular second premolars) ( 29364747)	A body shape index ( 34021172) Estimated glomerular filtration rate ( 30604766 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		34 interacting genes: ALX4 ALYREF AURKA BAX BUB1 CDX1 CTNNB1 DPYSL2 EP300 KPNA1 KPNA2 MITF MLH1 MLH3 MSH2 NFE2L2 NLK NOTCH1 NRAS PIAS4 PITX2 RB1 RUNX2 SMAD1 SMAD2 SMAD3 SMAD4 STK11 SUMO2 TLE1 TLE2 TRA UBTF ZBTB3	85 interacting genes: APEX1 ARFIP2 ARPC2 ATF3 ATF4 ATM ATR BPTF BRPF1 BRPF3 BTRC CASP1 CASP3 CDH1 CEBPG CERS2 CFAP299 CHD6 CLIC6 COPS7A CREB3 CREBBP CREBL2 CREBZF DDIT3 EIF2AK3 EIF3J ELF1 ELF3 ELF4 ELF5 ELK1 ETV1 ETV4 ETV6 FBXW11 FOSB FOSL2 GSK3B HNRNPR IRF2 JUN JUND KDM1A KEAP1 KPNA2 KPNA3 KPNA4 LEF1 MAFF MAFG MAFK MAP2K6 MAPK7 MAPK8 NCOR2 NFAT5 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX REL RELA SMAD1 SP140 SPIC STAT3 SUMO1 SUMO2 TADA2A TBP TEF TIGAR TNNT1 TRIM24 TRIM41 USP11 USP8 WAC ZBTB24 ZNF396
Entrez ID		51176	4780
HPRD ID		01075	02732
Ensembl ID		ENSG00000138795	ENSG00000116044
Uniprot IDs		Q9UJU2	A0A8V8TN14 A0A8V8TPA8 Q16236
PDB IDs			2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V 7K28 7K29 7K2A 7K2B 7K2C 7K2D 7K2E 7K2K 7O7B 7X5E 7X5F 7X5G 8EJR 8EJS
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Nucleoplasm Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process I-SMAD Binding Axis Specification Animal Organ Morphogenesis Pattern Specification Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Tube Development SMAD Protein Complex Positive Regulation Of Metabolic Process Heteromeric SMAD Protein Complex Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of RNA Metabolic Process Cell Fate Commitment Embryonic Pattern Specification Regionalization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Cell Population Proliferation Regulation Of Wnt Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Anterior/posterior Pattern Specification Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Developmental Growth Regulation Of Metabolic Process Wnt Signaling Pathway Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm RNA Polymerase II Transcription Regulator Complex Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Integrated Stress Response Signaling Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Transcription By RNA Polymerase II Cellular Response To Stress Response To Stress Chromatin Binding Transcription Regulator Complex Cellular Response To Chemical Stress
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