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LEF1 and ZBTB3
Number of citations of the paper that reports this interaction (PubMedID
20211142
)
41
Data Source:
BioGRID
(two hybrid)
LEF1
ZBTB3
Description
lymphoid enhancer binding factor 1
zinc finger and BTB domain containing 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Protein-DNA Complex
RNA Polymerase II Transcription Regulator Complex
Beta-catenin-TCF Complex
Nucleus
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
DNA Binding, Bending
Nuclear Estrogen Receptor Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Gamma-catenin Binding
Armadillo Repeat Domain Binding
C2H2 Zinc Finger Domain Binding
Transcription Regulator Inhibitor Activity
Sequence-specific Double-stranded DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Branching Involved In Blood Vessel Morphogenesis
Osteoblast Differentiation
Somitogenesis
Epithelial To Mesenchymal Transition
Vasculature Development
Sprouting Angiogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Wnt Signaling Pathway
Dentate Gyrus Development
Hippocampus Development
Forebrain Radial Glial Cell Differentiation
Forebrain Neuroblast Division
Formation Of Radial Glial Scaffolds
Regulation Of Cell-cell Adhesion
Regulation Of Wnt Signaling Pathway
Cell Differentiation
Positive Regulation Of Wnt Signaling Pathway
Neutrophil Differentiation
Embryonic Limb Morphogenesis
Positive Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of Granulocyte Differentiation
Mammary Gland Development
Negative Regulation Of Interleukin-13 Production
Negative Regulation Of Interleukin-4 Production
Negative Regulation Of Interleukin-5 Production
T Cell Receptor V(D)J Recombination
B Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Tongue Development
Host-mediated Activation Of Viral Transcription
T-helper 1 Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Cell Differentiation
Negative Regulation Of Striated Muscle Tissue Development
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Paraxial Mesoderm Formation
Cell Development
Regulation Of Neurogenesis
Sensory Perception Of Taste
Anatomical Structure Regression
Canonical Wnt Signaling Pathway
Face Morphogenesis
Cell Chemotaxis
Apoptotic Process Involved In Morphogenesis
Chorio-allantoic Fusion
Trachea Gland Development
Secondary Palate Development
Protein Localization To Chromatin
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-4
Positive Regulation Of Cell Proliferation In Bone Marrow
Negative Regulation Of Apoptotic Process In Bone Marrow Cell
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Odontoblast Differentiation
Apoptotic Process Involved In Blood Vessel Morphogenesis
Positive Regulation Of Chondrocyte Proliferation
Epithelial Cell Apoptotic Process
Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin
Regulation Of Transcription By RNA Polymerase II
Pathways
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Binding of TCF/LEF:CTNNB1 to target gene promoters
Repression of WNT target genes
Repression of WNT target genes
Transcriptional Regulation by VENTX
RUNX3 regulates WNT signaling
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Cardiogenesis
Germ layer formation at gastrulation
Formation of paraxial mesoderm
Formation of axial mesoderm
Somitogenesis
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Transcriptional and post-translational regulation of MITF-M expression and activity
Regulation of PD-L1(CD274) transcription
Drugs
Etacrynic acid
Diseases
GWAS
Airflow obstruction (
22837378
)
Blond vs. brown/black hair color (
30531825
)
Chronic lymphocytic leukemia (
23770605
26956414
28165464
)
Diastolic blood pressure (
27841878
)
Medication use (calcium channel blockers) (
31015401
)
Metabolic traits (
19060910
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
22291604
)
Systolic blood pressure (
27841878
30578418
)
Tooth agenesis (mandibular second premolars) (
29364747
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
34 interacting genes:
ALX4
ALYREF
AURKA
BAX
BUB1
CDX1
CTNNB1
DPYSL2
EP300
KPNA1
KPNA2
MITF
MLH1
MLH3
MSH2
NFE2L2
NLK
NOTCH1
NRAS
PIAS4
PITX2
RB1
RUNX2
SMAD1
SMAD2
SMAD3
SMAD4
STK11
SUMO2
TLE1
TLE2
TRA
UBTF
ZBTB3
24 interacting genes:
ANKRD2
AP1M1
BIN1
EIF5B
FOXM1
GATA4
GTF2A1L
IKBKG
IRF6
JADE2
LEF1
MYO15B
NR3C1
PKNOX1
PPARG
PROX1
SKIL
SMAD3
SMYD1
SSX3
SUPT5H
THRA
ZMYM2
ZNF556
Entrez ID
51176
79842
HPRD ID
01075
15693
Ensembl ID
ENSG00000138795
ENSG00000185670
Uniprot IDs
Q9UJU2
A0A6E1W9L1
PDB IDs
Enriched GO Terms of Interacting Partners
?
Transcription Regulator Complex
Nucleoplasm
Chromatin Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Factor Binding
Positive Regulation Of Macromolecule Metabolic Process
I-SMAD Binding
Axis Specification
Animal Organ Morphogenesis
Pattern Specification Process
Ubiquitin Protein Ligase Binding
Regulation Of Primary Metabolic Process
Tube Development
SMAD Protein Complex
Positive Regulation Of Metabolic Process
Heteromeric SMAD Protein Complex
Signal Transduction
SMAD Protein Signal Transduction
Positive Regulation Of RNA Metabolic Process
Cell Fate Commitment
Embryonic Pattern Specification
Regionalization
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Population Proliferation
Regulation Of Wnt Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Developmental Process
Positive Regulation Of Biosynthetic Process
Regulation Of Canonical Wnt Signaling Pathway
Anterior/posterior Pattern Specification
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Wnt Signaling Pathway
Developmental Growth
Regulation Of Metabolic Process
Wnt Signaling Pathway
Intracellular Signaling Cassette
Cell Surface Receptor Signaling Pathway
Regulation Of Gene Expression
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Sequence-specific DNA Binding
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Cis-regulatory Region Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA-binding Transcription Factor Activity
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Nucleus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
DNA Binding
Epithelial Cell Differentiation
Animal Organ Development
Negative Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Binding Domain Binding
Positive Regulation Of Biosynthetic Process
DNA-templated Transcription
Myeloid Cell Differentiation
Cell Differentiation
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Regulator Complex
Gland Development
Transdifferentiation
LBD Domain Binding
Chromatin Binding
Tube Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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