COPS4 and COPS6

Number of citations of the paper that reports this interaction (PMID 11337588)
171

Data Source:
BioGRID (pull down, biochemical)
HPRD (in vitro)

		COPS4	COPS6
Gene Name		COP9 signalosome subunit 4	COP9 signalosome subunit 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Synaptic Vesicle COP9 Signalosome Cell Junction Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm COP9 Signalosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Deneddylation Cullin Deneddylation	Cullin Deneddylation Viral Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: C19orf57 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 FOS IKBKB JUN MBIP RCBTB2 TP53 USHBP1 YWHAQ	84 interactors: ANXA1 ANXA7 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 JUN LAMA4 LPL MAP7D1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 VIM WIPI2 ZEB2 ZNF24
Entrez ID		51138	10980
HPRD ID		09888	16735
Ensembl ID		ENSG00000138663	ENSG00000168090
Uniprot IDs		B3KM48 Q9BT78	Q7L5N1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Protein Modification Process Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Signal Transduction Response To Radiation Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Cellular Response To Extracellular Stimulus Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Calcium Ion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Innate Immune Response Response To Growth Factor Negative Regulation Of Nucleic Acid-templated Transcription SMAD Protein Signal Transduction Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitochondrion Organization	Cullin Deneddylation Protein Deneddylation Developmental Process Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Catalytic Activity Tissue Development Mitotic Cell Cycle Programmed Cell Death Apoptotic Signaling Pathway Response To Stress Cell Death Catabolic Process Death Regulation Of Cell Proliferation Mitotic Cell Cycle Process Cellular Response To Stress Response To Abiotic Stimulus G1/S Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Phosphorylation Response To Organic Cyclic Compound Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Organ Development Multicellular Organismal Development Epithelium Development Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death System Development Negative Regulation Of Cell Death Cellular Macromolecule Catabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Positive Regulation Of Cell Death
Tagcloud ?			aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Difference) ?			aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Intersection) ?