COPS4 and RAB18

Number of citations: 44 (PubMedID 37091236)
Data Source: BioGRID (pull down)

		COPS4	RAB18
Name		COP9 signalosome subunit 4	RAB18, member RAS oncogene family
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction Cytoplasmic Vesicle Protein-containing Complex Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Secretory Granule Membrane Cis-Golgi Network Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding DeNEDDylase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation	Eye Development Intracellular Protein Transport Small GTPase-mediated Signal Transduction Brain Development Protein Transport Lipid Droplet Organization Endoplasmic Reticulum Tubular Network Organization
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Diseases		None	Warburg micro syndrome
GWAS		Metabolite levels ( 23823483 )	A body shape index ( 34021172 ) Benign childhood epilepsy with centro-temporal spikes ( 32580138 ) Childhood ear infection ( 27182965 28928442 ) Diisocyanate-induced asthma ( 25918132 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 28552196 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		None recorded	5 novel interactors: APBB1IP DVL3 PRTFDC1 TREH UCN
Interacting Genes		28 interacting genes: BRME1 CCDC85B CEBPA COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 DSCR9 FOS GPS1 HUNK IKBKB IL1RN KRT19 LCOR MBIP PCDHB12 PEX14 RAB18 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ	11 interacting genes: AQP6 CHM COPS4 ELOVL4 ERRFI1 FAM107A PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1
Entrez ID		51138	22931
HPRD ID		09888	03731
Ensembl ID		ENSG00000138663	ENSG00000099246
Uniprot IDs		A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78	B7Z4P9 Q9NP72
PDB IDs		4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	1X3S
GO Terms Enriched among Interactors		Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process COP9 Signalosome Assembly Protein Modification Process Intracellular Signaling Cassette Cytosol Regulation Of Primary Metabolic Process Negative Regulation Of Mitophagy Metal-dependent Deubiquitinase Activity Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cul5-RING Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Cytokine-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor DNA-templated Transcription Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Stem Cell Proliferation Nucleus Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Nuclear Matrix Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Response To Glucocorticoid Cellular Response To Hypoxia Medium-term Memory Cellular Response To Prolactin Protein Metabolic Process Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity Peroxisome Transport Along Microtubule	Meiotic Sister Chromatid Cohesion, Centromeric Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Autophosphorylation Protein Phosphatase Type 2A Complex Small GTPase Binding Response To Glucocorticoid Response To Corticosteroid Nitrate Transmembrane Transporter Activity Meiotic Spindle Elongation Sister Chromatid Cohesion Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Phosphatase Regulator Activity Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Response To Steroid Hormone Trehalose Metabolic Process Trehalose Catabolic Process Alpha,alpha-trehalase Activity