PCCA and PJA1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
0

Data Source:
BioGRID (enzymatic study)

		PCCA	PJA1
Description		propionyl-CoA carboxylase subunit alpha	praja ring finger ubiquitin ligase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex	Cytoplasm
	Molecular Function	Nucleotide Binding Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Ligase Activity, Forming Carbon-carbon Bonds Enzyme Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Branched-chain Amino Acid Metabolic Process Lipid Catabolic Process Short-chain Fatty Acid Catabolic Process	Protein Ubiquitination Protein Catabolic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Biotin
Diseases		Propionic acidemia
GWAS		Chromosomal aberration frequency (chromatid type) in genotoxic compound exposure ( 31586183) Corpus callosum anterior volume ( 31530798) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 23396134 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		6 interacting genes: ERRFI1 H19 MCC PCCB PJA1 TMEM132D	63 interacting genes: ABR ASCC2 ATP5F1C ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 DYRK1A EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		5095	64219
HPRD ID		01981	02335
Ensembl ID		ENSG00000175198	ENSG00000181191
Uniprot IDs		P05165	Q8NG27
PDB IDs		2CQY 2JKU 7YBU 8XL3 8XL4 8XL5	2L0B
Enriched GO Terms of Interacting Partners?			Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Proteolysis Protein Modification Process Peptidase Activity Deubiquitinase Activity Cytosol ATP Binding Pronucleus Ubiquitin Binding Protein K48-linked Deubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Chromatin Silencing Complex Protein Polyubiquitination Macromolecule Metabolic Process Facultative Heterochromatin Formation ESC/E(Z) Complex Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cysteine-type Endopeptidase Activity DNA Repair Regulation Of Proteasomal Protein Catabolic Process Mitotic Cytokinesis Transferase Activity Protein K63-linked Deubiquitination DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hydrolase Activity Protein Modification By Small Protein Conjugation DeNEDDylase Activity Sex Chromatin DNA Metabolic Process Ubiquitin-protein Transferase Activity Cytoskeleton-dependent Cytokinesis Kinase Activity Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Antibiotic Negative Regulation Of Signal Transduction By P53 Class Mediator
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