PCCA and H19

Number of citations of the paper that reports this interaction (PubMedID 37298108)
45

Data Source:
BioGRID (unspecified method)

		PCCA	H19
Description		propionyl-CoA carboxylase subunit alpha	H19 imprinted maternally expressed transcript
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Catalytic Complex
	Molecular Function	Nucleotide Binding Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Ligase Activity, Forming Carbon-carbon Bonds Enzyme Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Branched-chain Amino Acid Metabolic Process Lipid Catabolic Process Short-chain Fatty Acid Catabolic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism
Drugs		Biotin
Diseases		Propionic acidemia	Russell-Silver syndrome; Silver-Russell syndrome Beckwith-Wiedemann syndrome
GWAS		Chromosomal aberration frequency (chromatid type) in genotoxic compound exposure ( 31586183) Corpus callosum anterior volume ( 31530798) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 23396134 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Celiac disease ( 23936387) Creatinine levels ( 29403010) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (parent-of-origin) ( 23725790) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hypertension ( 30487518) Pulse pressure ( 27841878) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878 28135244) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		6 interacting genes: ERRFI1 H19 MCC PCCB PJA1 TMEM132D	21 interacting genes: BCLAF1 DDX5 DSP ESRP1 FMR1 IFIT5 ILF2 MYO1D NSD2 PCCA PCCB PPP1R3E PRKRA SERBP1 SRSF10 SRSF8 SRSF9 SSB STON2 TPM1 U2SURP
Entrez ID		5095	283120
HPRD ID		01981
Ensembl ID		ENSG00000175198	ENSG00000130600
Uniprot IDs		P05165
PDB IDs		2CQY 2JKU 7YBU 8XL3 8XL4 8XL5
Enriched GO Terms of Interacting Partners?			RNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome RNA Processing Regulation Of MRNA Processing Propionyl-CoA Carboxylase Activity Regulation Of MRNA Metabolic Process Poly(U) RNA Binding RNA Splicing MRNA Metabolic Process MRNA Processing Short-chain Fatty Acid Catabolic Process Ribonucleoprotein Complex SiRNA Binding Sequence-specific MRNA Binding Nuclear Speck Translation Repressor Activity Short-chain Fatty Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Gene Expression Regulation Of Viral Life Cycle Catalytic Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Branched-chain Amino Acid Metabolic Process MRNA Catabolic Process Negative Regulation Of RNA Splicing MRNA 3'-UTR Binding Regulation Of Viral Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus MRNA Splice Site Recognition MiRNA Processing Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process MiRNA Transcription Positive Regulation Of Intracellular Transport Of Viral Material Ligase Activity, Forming Carbon-carbon Bonds Nuclear Histone MRNA Catabolic Process Positive Regulation Of Heart Rate By Epinephrine Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Primary Metabolic Process RNA Catabolic Process Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Metabolic Process
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