MARK2 and PKD1

Number of citations of the paper that reports this interaction (PMID 19011111)
20

Data Source:
BioGRID (enzymatic study)

		MARK2	PKD1
Gene Name		MAP/microtubule affinity-regulating kinase 2	polycystic kidney disease 1 (autosomal dominant)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Basal Cortex Microtubule Bundle	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Primary Cilium Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Poly(A) RNA Binding Tau-protein Kinase Activity	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Ion Channel Binding
	Biological Process	Mitochondrion Degradation Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Nitrogen Compound Metabolic Process Organelle Organization Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration JAK-STAT Cascade Heart Development Anatomical Structure Morphogenesis Single Organismal Cell-cell Adhesion Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Binding Response To Fluid Shear Stress Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: BAIAP2 CAMK1 DVL3 GAB1 GSK3B HDAC7 KIF13B MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD6A PINK1 PKD1 PRKCE RAB11FIP2 RNF41 STK11 UTRN YWHAB YWHAQ YWHAZ	25 interactors: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 MARK2 PKD2 PTK2 PXN RGS7 SIAH1 SRC TLN1 VCL VIM
Entrez ID		2011	5310
HPRD ID		02753	03203
Ensembl ID		ENSG00000072518	ENSG00000008710
Uniprot IDs		A8K2S4 Q7KZI7	P98161
PDB IDs		3IEC	1B4R
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Cellular Localization Regulation Of Intracellular Transport Signaling Positive Regulation Of Signal Transduction Cell Communication Positive Regulation Of Transport Signal Transduction Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Protein Kinase Activity Regulation Of Signaling Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Protein Localization Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Neuron Projection Development Negative Regulation Of Transport Regulation Of MAPK Cascade Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Protein Modification Process Negative Regulation Of Sodium Ion Transport Regulation Of Establishment Of Protein Localization Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Regulation Of Cell Projection Organization Cell Death Death Response To Stimulus Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Sodium Ion Transport	Adherens Junction Organization Cytoskeleton Organization Movement Of Cell Or Subcellular Component Cell Junction Assembly Cell-cell Junction Organization Cellular Response To Organonitrogen Compound Regulation Of Cellular Component Movement Organelle Organization Cellular Response To Organic Substance Cellular Response To Indole-3-methanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Activation Regulation Of Body Fluid Levels Response To Organic Substance Response To Organonitrogen Compound Blood Coagulation Regulation Of Cell Motility Hemostasis Anatomical Structure Development Cell Development Cell Adhesion Adherens Junction Assembly Cellular Component Assembly Regulation Of Locomotion Cell-cell Junction Assembly Cell Activation Response To Wounding Generation Of Neurons Cell Morphogenesis Involved In Differentiation Locomotion Anatomical Structure Morphogenesis Cell Differentiation Neurogenesis Multicellular Organismal Development Developmental Process System Development Response To Stimulus Regulation Of Cell Migration Wound Healing Actin Filament-based Process Nervous System Development Response To Peptide Hormone Cellular Localization Response To Stress Response To Peptide Cellular Response To Peptide Hormone Stimulus Protein Complex Assembly Cellular Response To Peptide Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility
Tagcloud ?		adjusting aor assisted backgroundlimited children china conclusionsscreen habits height hrs inverted lifestyle mark0 methodsa modes multilevel obese obesity overweight question questions results15 school schools screen spent travel	acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd2 polycystic polycystin progressive severity
Tagcloud (Difference) ?		adjusting aor assisted backgroundlimited children china conclusionsscreen habits height hrs inverted lifestyle mark0 methodsa modes multilevel obese obesity overweight question questions results15 school schools screen spent travel	acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd2 polycystic polycystin progressive severity
Tagcloud (Intersection) ?