MARK2 and PARD6A

Number of citations of the paper that reports this interaction (PMID 14676191)
42

Data Source:
HPRD (in vivo)

		MARK2	PARD6A
Gene Name		MAP/microtubule affinity-regulating kinase 2	par-6 family cell polarity regulator alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Basal Cortex Microtubule Bundle	Ruffle Nucleus Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Poly(A) RNA Binding Tau-protein Kinase Activity	Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding GTP-dependent Protein Binding
	Biological Process	Mitochondrion Degradation Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization	Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell Junction Assembly Cell-cell Junction Organization Cell-cell Junction Maintenance Cell Division Tight Junction Assembly
Pathways			Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		23 interactors: BAIAP2 CAMK1 DVL3 GAB1 GSK3B HDAC7 KIF13B MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD6A PINK1 PKD1 PRKCE RAB11FIP2 RNF41 STK11 UTRN YWHAB YWHAQ YWHAZ	24 interactors: CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ RAC1 RHOQ TCP10 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		2011	50855
HPRD ID		02753	06316
Ensembl ID		ENSG00000072518	ENSG00000102981
Uniprot IDs		A8K2S4 Q7KZI7	Q9NPB6
PDB IDs		3IEC	1WMH
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Cellular Localization Regulation Of Intracellular Transport Signaling Positive Regulation Of Signal Transduction Cell Communication Positive Regulation Of Transport Signal Transduction Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Positive Regulation Of Organelle Organization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Protein Kinase Activity Regulation Of Signaling Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Protein Localization Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Neuron Projection Development Negative Regulation Of Transport Regulation Of MAPK Cascade Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Protein Modification Process Negative Regulation Of Sodium Ion Transport Regulation Of Establishment Of Protein Localization Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Regulation Of Cell Projection Organization Cell Death Death Response To Stimulus Positive Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Sodium Ion Transport	Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Junction Organization Nervous System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Tight Junction Assembly Signal Transduction Regulation Of Cell Death Regulation Of Cellular Component Organization System Development Positive Regulation Of Signal Transduction Apical Junction Assembly Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Transport Establishment Or Maintenance Of Cell Polarity Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cell Junction Assembly Multicellular Organismal Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Programmed Cell Death Response To Growth Factor Generation Of Neurons Wound Healing Anatomical Structure Development Cellular Response To Stimulus Positive Regulation Of Cell Death Cell-cell Junction Assembly Neurogenesis Regulation Of Establishment Of Protein Localization Regulation Of Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Protein Phosphorylation Developmental Process Regulation Of Protein Localization Regulation Of Kinase Activity Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation
Tagcloud ?		adjusting aor assisted backgroundlimited children china conclusionsscreen habits height hrs inverted lifestyle mark0 methodsa modes multilevel obese obesity overweight question questions results15 school schools screen spent travel
Tagcloud (Difference) ?		adjusting aor assisted backgroundlimited children china conclusionsscreen habits height hrs inverted lifestyle mark0 methodsa modes multilevel obese obesity overweight question questions results15 school schools screen spent travel
Tagcloud (Intersection) ?