MARK2 and PLAAT3

		MARK2	PLAAT3
Description		microtubule affinity regulating kinase 2	phospholipase A and acyltransferase 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Phospholipase Activity Phospholipase A2 Activity Protein Binding Lipid Binding Phospholipase A1 Activity N-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly	Lipid Metabolic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Peroxisome Organization Phospholipid Biosynthetic Process Response To Bacterium Lipid Catabolic Process Membrane Disassembly Phosphatidylethanolamine Acyl-chain Remodeling Ether Lipid Metabolic Process N-acylphosphatidylethanolamine Metabolic Process Lens Fiber Cell Differentiation Organelle Disassembly Regulation Of Adipose Tissue Development
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI
Drugs		Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		31 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L PAK5 PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 YWHAB YWHAZ	5 interacting genes: NRIP1 PPP2R1A UBQLN1 UBQLN2 UBQLN4
Entrez ID		2011	11145
HPRD ID		02753	13671
Ensembl ID		ENSG00000072518	ENSG00000176485
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	P53816
PDB IDs		3IEC 5EAK 5KZ7 5KZ8 8TXY	2KYT 4DOT 4FA0 4Q95 7C3Z 7C41 7ZOM
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding	Polyubiquitin Modification-dependent Protein Binding Autophagy Autophagosome Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Response To Endoplasmic Reticulum Stress Catabolic Process Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Autophagy Lateral Plasma Membrane Meiotic Spindle Elongation Ovarian Follicle Rupture Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Regulation Of Cellular Response To Stress Modification-dependent Protein Catabolic Process Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Nuclear Proteasome Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Proteolysis Involved In Protein Catabolic Process Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Meiotic Sister Chromatid Cohesion, Centromeric Organelle Assembly Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Microtubule Bundle Mitotic Sister Chromatid Separation Spindle Elongation Cytosolic Proteasome Complex Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Proteolysis Cytoplasmic Vesicle Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Protein Antigen Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand K48-linked Polyubiquitin Modification-dependent Protein Binding Chromosome Separation
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