MARK2 and OSBP

Data Source: HiPPIP (Novel)

		MARK2	OSBP
Name		microtubule affinity regulating kinase 2	oxysterol binding protein
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Protein Binding Oxysterol Binding Lipid Binding Protein Domain Specific Binding Sterol Binding Phosphatidylinositol-4-phosphate Binding Lipid Transfer Activity Sterol Transfer Activity
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly	Sphingomyelin Biosynthetic Process Bile Acid Biosynthetic Process Lipid Transport Phospholipid Transport Sterol Transport Intracellular Cholesterol Transport Ceramide Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intermembrane Lipid Transfer Positive Regulation Of Secretory Granule Organization
Pathways		None	Sphingolipid de novo biosynthesis Synthesis of bile acids and bile salts
Drugs		Fostamatinib	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132 )	No GWAS studies recorded
Interacting Genes		31 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L PAK5 PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 YWHAB YWHAZ	4 interacting genes: CSNK2A1 SNAP25 VAPA VAPB
Entrez ID		2011	5007
HPRD ID		02753	01327
Ensembl ID		ENSG00000072518	ENSG00000110048
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	P22059
PDB IDs		3IEC 5EAK 5KZ7 5KZ8 8TXY	2RR3 7V62
GO Terms Enriched among Interactors		Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding	FFAT Motif Binding COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization By Membrane Tethering Membrane Docking Endoplasmic Reticulum Localization Organelle Localization Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Viral Release From Host Cell Endoplasmic Reticulum Exit Site Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process Cadherin Binding Vesicle Organization Organelle Organization Endoplasmic Reticulum Organization Cholesterol Transport Host-mediated Perturbation Of Viral Process Sterol Transport Establishment Of Localization In Cell Host-mediated Perturbation Of Symbiont Process Modulation Of Process Of Another Organism Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation By Virus Of Viral Protein Levels In Host Cell Viral Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Membrane Fusion Biological Process Involved In Interaction With Host Organic Hydroxy Compound Transport Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Plasma Membrane Protein Folding Positive Regulation Of Aggrephagy Microtubule Bundle Ribbon Synapse Regulation Of Neurofibrillary Tangle Assembly Neuronal Dense Core Vesicle Exocytosis Host-mediated Perturbation Of Viral RNA Genome Replication Microtubule Binding Regulation Of Biological Quality Dense Core Granule Exocytosis Wnt Signaling Pathway