MARK2 and PAK5

Number of citations: 53 (PubMedID 16014608)
Data Source: BioGRID (two hybrid, pull down, affinity chromatography technology)

		MARK2	PAK5
Name		microtubule affinity regulating kinase 2	p21 (RAC1) activated kinase 5
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Membrane Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		None	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle
Drugs		Fostamatinib	Fostamatinib
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132 )	Atopy ( 28927820 ) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 )
Interacting Genes		31 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L PAK5 PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 YWHAB YWHAZ	36 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MARK2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 SRSF11 TSGA10 TUBGCP4 UXT
Entrez ID		2011	57144
HPRD ID		02753	06423
Ensembl ID		ENSG00000072518	ENSG00000101349
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	B0AZM9 Q9P286
PDB IDs		3IEC 5EAK 5KZ7 5KZ8 8TXY	2F57 8C12
GO Terms Enriched among Interactors		Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding	Cytoskeleton Organization Cytoskeleton Cytoplasm Wnt Signaling Pathway Microtubule-based Process Microtubule Nucleation Microtubule Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cell Projection Assembly Spindle Non-canonical Wnt Signaling Pathway Thioesterase Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Centrosome Establishment Or Maintenance Of Cell Polarity Midbrain Dopaminergic Neuron Differentiation Cellular Component Assembly GTP-dependent Protein Binding Cytoplasmic Ribonucleoprotein Granule Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Tau-protein Kinase Activity Establishment Of Cell Polarity Regulation Of Stress Fiber Assembly