MARK2 and CREBBP

Number of citations: 72 (PubMedID 35469920)
Data Source: BioGRID (affinity chromatography technology, enzymatic study)

		MARK2	CREBBP
Name		microtubule affinity regulating kinase 2	CREB binding lysine acetyltransferase
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle	Histone Acetyltransferase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Transcription Coactivator Binding P53 Binding Chromatin Binding Damaged DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Chromatin DNA Binding MRF Binding Histone H3K18 Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Metal Ion Binding Tau Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity DNA-binding Transcription Factor Binding
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase I N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Destabilization Cellular Response To Nutrient Levels Cellular Response To UV Homeostatic Process Embryonic Digit Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Protein-containing Complex Assembly Protein K48-linked Deubiquitination Energy Homeostasis Regulation Of Cellular Response To Heat Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		None	Regulation of gene expression by Hypoxia-inducible Factor BMAL1:CLOCK,NPAS2 activates circadian expression Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1 Heme signaling Nuclear events mediated by NFE2L2 NPAS4 regulates expression of target genes Formation of paraxial mesoderm NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Zygotic genome activation (ZGA) Evasion by RSV of host interferon responses MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional and post-translational regulation of MITF-M expression and activity Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		Fostamatinib	Colforsin 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Diseases		None	Rubinstein-Taybi syndrome
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132 )	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Metabolite levels (HVA/5-HIAA ratio) ( 23319000 ) Neutrophil count ( 32888494 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Nonsyndromic cleft lip with or without cleft palate ( 25775280 ) Obesity-related traits ( 23251661 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) QT interval ( 24952745 ) QT interval (drug interaction) ( 23459443 ) White blood cell count ( 32888494 )
Interacting Genes		31 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L PAK5 PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 YWHAB YWHAZ	364 interacting genes: ACSS1 ACTA2 ACTB ACVR1 AFP AIRE AKT1 ALX1 ANAPC5 ANAPC7 ANKS1A ANKS1B ANXA7 AP1B1 APC APP AR ATF1 ATF3 ATF4 ATF7IP ATRX BAG5 BCL3 BCL6 BRCA1 BRIP1 CALCOCO1 CAMK4 CAMSAP2 CARM1 CASP8AP2 CBX4 CDC25B CDH2 CDK5RAP3 CDX2 CEBPA CEBPB CEBPD CEP290 CHAF1A CHD3 CHRDL1 CHUK CIITA CITED1 CITED2 CLASP2 CNOT3 CNTRL CPAP CPSF4 CREB1 CREM CRX CSK CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CUX1 DACH1 DAXX DDX17 DDX5 DEK E2F1 E2F5 EBF1 EEF1A1 EEF2 EGR1 EID1 EID3 EIF2B1 EIF3D EIF4G2 ELF3 ELK1 EP300 EPG5 ESR1 ETS1 ETS2 EWSR1 EXOC5 FAF1 FBXL19 FBXO38 FGFR1 FHL2 FOXH1 FOXM1 FOXO1 FOXO3 FOXO4 FUS GAA GABPA GAK GATA1 GATAD2A GCM1 GLI3 GMEB1 GMEB2 GPR161 GRIA3 GSTO2 GTF2B H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H4C16 HBP1 HCK HDAC1 HDAC3 HEXA HIF1A HIPK1 HIPK2 HIPK3 HIVEP1 HIVEP2 HLF HMG20A HMGA1 HMGB1 HMGB2 HMGXB4 HNF1A HNF1B HNF4A HNRNPL HOXA10 HOXA11 HOXA9 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD12 HOXD13 HOXD4 HSF1 HTT HUWE1 IKBKG IQGAP1 IRF1 IRF3 IRF5 IRF7 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KDM2B KDM3B KDM6A KDM6B KHDRBS1 KIF5A KISS1 KLF1 KLF13 KLF4 KLF5 KMT2A KMT2D KPNA2 KPNA6 LATS1 LDLR LIG4 LYN MAF MAFG MAML1 MAML2 MAP1B MAP3K5 MAPK1 MAPK10 MAPK3 MAPT MARK2 MBD2 MDC1 MDM2 MECOM MED25 MGMT MIER1 MKNK1 MOB1A MSH2 MSH6 MSX1 MYB MYBL1 MYBL2 MYC MYO1E MYOD1 N4BP2 NAP1L1 NCOA1 NCOA2 NCOA3 NCOA6 NEUROG1 NFATC2 NFATC4 NFE2 NFE2L2 NFIA NFIC NKX2-1 NLK NPAS2 NPAT NR3C1 NR5A1 NUP98 OGT ONECUT1 PAPPA PAX5 PBX1 PCMT1 PCNA PELP1 PHLDA1 PHOX2A PIAS1 PIAS2 PIAS3 PLAGL1 PML POLR2A POU1F1 POU2F3 PPARGC1A PPP1R8 PPP2R2A PRKCD PRKCZ PRLR PROX1 PSME3 PTMA PTPRF RAD23A RAD50 RBBP4 RBBP7 RBCK1 RBM24 RBM5 RELA RFK RNF111 RNF7 RPL3 RPL35 RPS20 RPS6KA1 RPS6KA3 RPS6KA5 RXRG SEMA3B SEPTIN3 SERTAD1 SERTAD2 SERTAD3 SETDB1 SH3GL1 SHCBP1 SLC1A4 SMAD1 SMAD2 SMAD3 SMAD4 SNAI1 SNAI2 SNAPC5 SND1 SNIP1 SNRNP200 SOS2 SOX9 SP100 SPI1 SPIB SPTAN1 SRCAP SREBF1 SREBF2 SRF SS18L1 STAT1 STAT2 STAT3 STAT4 STAT6 SUMO1 SUV39H1 SYT1 TACC2 TAF6L TCF12 TCF3 TDG TFDP1 TGS1 THRA TIAL1 TIAM1 TOPORS TP53 TP53BP2 TP73 TRERF1 TRIM24 TRIP10 TRIP4 TSPYL2 TUBB UBE2D1 UBE2I UBTF UIMC1 VAT1L VDR WAS WDR77 WT1 XAF1 XRCC6 YTHDF2 YWHAH YY1 ZBTB17 ZBTB2 ZCCHC7 ZHX1 ZMYM2 ZMYM5 ZNF106 ZNF451 ZNF639 ZNFX1
Entrez ID		2011	1387
HPRD ID		02753	02534
Ensembl ID		ENSG00000072518	ENSG00000005339
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	Q92793
PDB IDs		3IEC 5EAK 5KZ7 5KZ8 8TXY	1JSP 1LIQ 1RDT 1WO3 1WO4 1WO5 1WO6 1WO7 1ZOQ 2D82 2KJE 2KWF 2L84 2L85 2LXS 2LXT 2N1A 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF 4TQN 4TS8 4WHU 4YK0 5CGP 5DBM 5EIC 5ENG 5EP7 5GH9 5H85 5I83 5I86 5I89 5I8B 5I8G 5J0D 5JEM 5KTU 5KTW 5KTX 5LPJ 5LPL 5MME 5MMG 5MPK 5MPN 5MPZ 5MQE 5MQG 5MQK 5NLK 5NRW 5NU3 5OWK 5SVH 5TB6 5W0E 5W0F 5W0L 5W0Q 5XXH 6ALB 6ALC 6AXQ 6AY3 6AY5 6DMK 6ES5 6ES6 6ES7 6FQO 6FQT 6FQU 6FR0 6FRF 6LQX 6M64 6QST 6SQE 6SQF 6SQM 6SXX 6YIJ 6YIK 6YIL 6YIM 7CO1 7EVJ 7JFL 7JFM 7JUO 7KPY 7RLE 7TB3 7TBH 7UGE 7UGL 7WX2 7XH6 7XHE 7XI0 7XIJ 7XM7 7XNE 7XNG 8FUP 8FV2 8FXA 8FXE 8FXN 8FXO 8G6T 8GA2 8HAL 8HAM 8HAN 9J6O 9JUU 9JUY
GO Terms Enriched among Interactors		Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin DNA Binding Positive Regulation Of Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Transcription Regulator Complex Chromatin Binding DNA-templated Transcription Regulation Of Developmental Process Cellular Developmental Process Regulation Of Cell Differentiation RNA Polymerase II Transcription Regulator Complex Cell Differentiation DNA-binding Transcription Factor Binding Developmental Process Chromatin Organization