MARK2 and KIF13B

Number of citations: 43 (PubMedID 20194617)
Data Source: BioGRID (pull down, enzymatic study)

		MARK2	KIF13B
Name		microtubule affinity regulating kinase 2	kinesin family member 13B
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Axon Cell Projection
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly	Protein Targeting Microtubule-based Movement Signal Transduction T Cell Activation Establishment Of Protein Localization Regulation Of Axonogenesis
Pathways		None	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs		Fostamatinib	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132 )	Apolipoprotein B levels ( 32203549 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Metabolite levels (X-11787) ( 23934736 ) Metabolite levels (HVA) ( 23319000 ) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000 ) PR interval in Tripanosoma cruzi seropositivity ( 24324551 ) Prostate cancer ( 33293427 ) Response to statin therapy ( 20339536 )
Interacting Genes		31 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L PAK5 PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 YWHAB YWHAZ	4 interacting genes: DLG1 DLG4 MARK2 SF3B3
Entrez ID		2011	23303
HPRD ID		02753	09556
Ensembl ID		ENSG00000072518	ENSG00000197892
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	Q9NQT8
PDB IDs		3IEC 5EAK 5KZ7 5KZ8 8TXY	2COW 3FM8 3GBJ 3MDB
GO Terms Enriched among Interactors		Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Morphogenesis Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Synaptic Membrane Lateral Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein-containing Complex Localization Neuromuscular Junction Protein Localization To Cell Junction Kinase Binding Postsynaptic Density Membrane P2Y1 Nucleotide Receptor Binding Regulation Of Cell Shape Regulation Of Anatomical Structure Morphogenesis Structural Constituent Of Postsynaptic Density Adherens Junction L27 Domain Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Cell Junction Positive Regulation Of Cellular Component Organization MPP7-DLG1-LIN7 Complex Protein Localization To Cell Periphery Maintenance Of Postsynaptic Density Structure Lateral Loop Myelin Sheath Abaxonal Region AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding Microtubule Bundle Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Postsynaptic Density Regulation Of Potassium Ion Import NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly U2 SnRNA Binding Protein-containing Complex Assembly D1 Dopamine Receptor Binding Negative Regulation Of P38MAPK Cascade Cortical Microtubule Organization Protein-containing Complex Organization Chemical Synaptic Transmission Hard Palate Development