PIK3C2B

Description		phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Endocytic Vesicle Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Lipid Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding
	Biological Process	Lipid Metabolic Process Cellular Response To Starvation Macroautophagy Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Autophagosome Organization
Pathways		Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib
Diseases
GWAS		Breast cancer ( 23535733) Facial morphology ( 29921221) FEV1 ( 30804560) Fish- and plant-related diet ( 32066663) Household income (MTAG) ( 31844048) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30804560) Oily fish consumption ( 32066663) Peak expiratory flow ( 30804560) Pork consumption ( 32066663) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889)
Interacting Genes		9 interacting genes: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 UBC
Entrez ID		5287
HPRD ID		04160
Ensembl ID		ENSG00000133056
Uniprot IDs		A2RUF7 F5GWN5 O00750
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Vesicle Enzyme-linked Receptor Protein Signaling Pathway Shc-EGFR Complex Clathrin-dependent Synaptic Vesicle Endocytosis Protein Tyrosine Kinase Activity Epidermal Growth Factor Binding Receptor Complex Peptidyl-tyrosine Phosphorylation Neurotrophin TRKA Receptor Binding Plasma Membrane ERBB2-EGFR Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cellular Component Organization Schwann Cell Development Presynaptic Membrane Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Cell Growth Positive Regulation Of Cell Communication Protein Kinase Activity Positive Regulation Of Signaling Receptor-mediated Endocytosis Ephrin Receptor Binding Positive Regulation Of ERK1 And ERK2 Cascade Clathrin-dependent Endocytosis Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAP Kinase Activity Protein-macromolecule Adaptor Activity Kinase Activity Synaptic Vesicle Endocytosis Positive Regulation Of Protein Phosphorylation Presynaptic Endocytosis Positive Regulation Of Growth Positive Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus
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