PIK3C2B

Gene Name		phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Endocytic Vesicle
	Molecular Function	Lipid Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Biological_process Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling
Pathways		Synthesis of PIPs at the plasma membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS		Breast cancer ( 23535733) Prostate cancer ( 23535732)
Protein-protein Interactions		9 interactors: EGFR ERBB2 GRB2 ITSN1 ITSN2 LTK PDGFRB SHC1 YWHAQ
Entrez ID		5287
HPRD ID		04160
Ensembl ID		ENSG00000133056
Uniprot IDs		A2RUF7 F5GWN5 O00750
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of MAP Kinase Activity Chemotaxis Regulation Of MAPK Cascade Locomotion Regulation Of Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAP Kinase Activity Regulation Of ERBB Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Phosphorylation System Development Regulation Of Immune Response Axon Guidance Peptidyl-amino Acid Modification Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA Metabolic Process Multicellular Organismal Development Cell Surface Receptor Signaling Pathway
Tagcloud ?		adj adjustment aggressiveness allele attributable consortium familial fatal gleason institute nearby per phosphatidylinositol pi3k pik3ap1 pik3r3 pooled prostate rs7556371 snp snps strengthened stronger strongest tertile top trend