PAH and PCBD1

Number of citations of the paper that reports this interaction (PMID 11461190)
0

Data Source:
BioGRID (two hybrid)

		PAH	PCBD1
Gene Name		phenylalanine hydroxylase	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Phenylalanine 4-monooxygenase Activity Iron Ion Binding Amino Acid Binding	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding
	Biological Process	L-phenylalanine Catabolic Process Cellular Amino Acid Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Neurotransmitter Biosynthetic Process Catecholamine Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Transcription, DNA-templated L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Homodimerization Activity Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Homotetramerization Protein Heterooligomerization Oxidation-reduction Process
Pathways		Phenylalanine and tyrosine catabolism Abnormal metabolism in phenylketonuria Metabolism of amino acids and derivatives	Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives
Drugs		L-Phenylalanine Tetrahydrobiopterin Norepinephrine Epinephrine Quinonoid 7,8-Tetrahydrobiopterin (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin Beta(2-Thienyl)Alanine 7,8-Dihydrobiopterin Norleucine Droxidopa
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: PCBD1 QDPR RPS24	49 interactors: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NUDT18 PAH PAPOLG PCBD2 POLR3A RBL2 RPS24 SAP30 SCMH1 SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WDYHV1 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF714
Entrez ID		5053	5092
HPRD ID		08943	00523
Ensembl ID		ENSG00000171759	ENSG00000166228
Uniprot IDs		P00439	P61457
PDB IDs		1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5PAH 6PAH
Enriched GO Terms of Interacting Partners?		Tetrahydrobiopterin Biosynthetic Process L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Aromatic Compound Catabolic Process Pteridine-containing Compound Biosynthetic Process Aromatic Amino Acid Family Metabolic Process Pteridine-containing Compound Metabolic Process Cellular Amino Acid Catabolic Process Coenzyme Biosynthetic Process Carboxylic Acid Catabolic Process Dihydrobiopterin Metabolic Process Alpha-amino Acid Metabolic Process Catabolic Process Cofactor Metabolic Process Response To Aluminum Ion Cellular Amino Acid Metabolic Process Regulation Of Protein Homodimerization Activity Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA Response To Lead Ion Ribosomal Small Subunit Biogenesis Carboxylic Acid Metabolic Process Response To Glucagon Organic Acid Metabolic Process Cellular Response To Drug Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Protein Homotetramerization Cellular Nitrogen Compound Metabolic Process Viral Transcription Oxidation-reduction Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Nitrogen Compound Metabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Protein Tetramerization Erythrocyte Homeostasis Protein Localization To Endoplasmic Reticulum RRNA Processing Protein Heterooligomerization RRNA Metabolic Process Myeloid Cell Homeostasis Translational Termination Regulation Of Protein Binding Nuclear-transcribed MRNA Catabolic Process Liver Development MRNA Catabolic Process	RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Metabolic Process Chromatin Remodeling Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Chromatin Organization Insulin Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Endocrine Pancreas Development Regulation Of Cellular Process Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Cellular Process Positive Regulation Of DNA-templated Transcription, Initiation Hormone Secretion
Tagcloud ?		ace anesthetized angiotensin ascribed b2 bradykinin cei clarify clearances converting deleterious fall gfr hemodynamic hoe indices inulin kinin kininases maintains microg neonatal newborn perindoprilat postglomerular rabbits reflected renin vasodilation
Tagcloud (Difference) ?		ace anesthetized angiotensin ascribed b2 bradykinin cei clarify clearances converting deleterious fall gfr hemodynamic hoe indices inulin kinin kininases maintains microg neonatal newborn perindoprilat postglomerular rabbits reflected renin vasodilation
Tagcloud (Intersection) ?