PCBD1 and RPS24

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		PCBD1	RPS24
Description		pterin-4 alpha-carbinolamine dehydratase 1	ribosomal protein S24
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Ribonucleoprotein Complex
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity Identical Protein Binding	RNA Binding Structural Constituent Of Ribosome Translation Initiation Factor Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of DNA-templated Transcription	Cytoplasmic Translation RRNA Processing Translation Erythrocyte Homeostasis Ribosomal Small Subunit Biogenesis
Pathways		Phenylalanine metabolism	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient	Diamond-Blackfan anemia (DBA)
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	California verbal learning test score ( 31596458) Diverticular disease ( 30177863) Metabolite levels ( 23823483)
Interacting Genes		53 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	9 interacting genes: CBR1 DUX4 ERCC6 OGT PAH PCBD1 PNISR STK17B TAF9
Entrez ID		5092	6229
HPRD ID		00523	03877
Ensembl ID		ENSG00000166228	ENSG00000138326
Uniprot IDs		P61457	A0A2R8Y849 P62847
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6MTD 6MTE 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7QVP 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Zinc Ion Binding Chromatin Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Frizzled Binding Epigenetic Regulation Of Gene Expression Metal Ion Binding Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TRNA Transcription By RNA Polymerase III TRNA Transcription Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Activity RSC-type Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition	Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Tyrosine Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Aromatic Amino Acid Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Carboxylic Acid Biosynthetic Process Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Negative Regulation Of Cell Cycle Process Positive Regulation Of Transcription By RNA Polymerase II Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Amino Acid Biosynthetic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II P53 Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Negative Regulation Of Cell Cycle Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process DNA Damage Checkpoint Signaling Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Small Molecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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