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PCBD1 and DENND4A
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
PCBD1
DENND4A
Gene Name
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
DENN/MADD domain containing 4A
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Vesicular Exosome
Nucleus
Molecular Function
Transcription Coactivator Activity
Phenylalanine 4-monooxygenase Activity
Protein Binding
4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity
Identical Protein Binding
DNA Binding
Rab Guanyl-nucleotide Exchange Factor Activity
Biological Process
Transcription, DNA-templated
L-phenylalanine Catabolic Process
Tetrahydrobiopterin Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Protein Homodimerization Activity
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Homotetramerization
Protein Heterooligomerization
Oxidation-reduction Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Positive Regulation Of Rab GTPase Activity
Pathways
Phenylalanine and tyrosine catabolism
Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Mean corpuscular hemoglobin (
20139978
)
Red blood cell traits (
23222517
)
Protein-Protein Interactions
49 interactors:
ACIN1
APP
BRD7
CACNA1C
CALCOCO1
CDK5RAP2
CEBPZ
DENND4A
DIP2C
DVL2
DYRK1B
EHMT1
FXR2
GORASP2
GTF3C3
HES4
HNF1A
HNF1B
HNF4A
KLF13
LNX1
MIS18BP1
NFKB1
NIF3L1
NUDT18
PAH
PAPOLG
PCBD2
POLR3A
RBL2
RPS24
SAP30
SCMH1
SMARCD1
SOWAHC
SUPT5H
TFF3
TIMELESS
TRIM5
WDYHV1
WWP1
ZBTB25
ZNF195
ZNF202
ZNF23
ZNF263
ZNF451
ZNF567
ZNF714
5 interactors:
CEBPE
PCBD1
SERTAD1
TLX3
YWHAG
Entrez ID
5092
10260
HPRD ID
00523
02662
Ensembl ID
ENSG00000166228
ENSG00000174485
Uniprot IDs
P61457
Q05C90
Q7Z401
PDB IDs
Enriched GO Terms of Interacting Partners
?
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
RNA Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cellular Nitrogen Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Gene Expression
Heterocycle Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Biosynthetic Process
Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Metabolic Process
Chromatin Remodeling
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Chromatin Organization
Insulin Secretion
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Chromosome Organization
Chromatin Modification
Endocrine Pancreas Development
Regulation Of Cellular Process
Peptide Hormone Secretion
Peptide Secretion
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Cellular Process
Positive Regulation Of DNA-templated Transcription, Initiation
Hormone Secretion
Positive Regulation Of Transcription, DNA-templated
Tetrahydrobiopterin Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
L-phenylalanine Catabolic Process
Positive Regulation Of Cellular Biosynthetic Process
L-phenylalanine Metabolic Process
Regulation Of Respiratory Gaseous Exchange By Neurological System Process
Regulation Of Metabolic Process
Regulation Of Respiratory System Process
Regulation Of Protein Homodimerization Activity
Macrophage Differentiation
Regulation Of Transcription, DNA-templated
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Neuron Differentiation
Cytokine Biosynthetic Process
Regulation Of Respiratory Gaseous Exchange
Regulation Of RNA Metabolic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cytokine Metabolic Process
Neuron Fate Specification
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Gene Expression
Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Pteridine-containing Compound Biosynthetic Process
Regulation Of Neurogenesis
RNA Biosynthetic Process
Regulation Of Protein Kinase Activity
Aromatic Amino Acid Family Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Respiratory Gaseous Exchange
Regulation Of Cell Development
Positive Regulation Of Mitochondrion Organization
Pteridine-containing Compound Metabolic Process
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