PAH and RPS24

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PAH	RPS24
Gene Name		phenylalanine hydroxylase	ribosomal protein S24
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit
	Molecular Function	Phenylalanine 4-monooxygenase Activity Iron Ion Binding Amino Acid Binding	Nucleotide Binding Structural Constituent Of Ribosome Translation Initiation Factor Binding Poly(A) RNA Binding
	Biological Process	L-phenylalanine Catabolic Process Cellular Amino Acid Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Neurotransmitter Biosynthetic Process Catecholamine Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Erythrocyte Homeostasis Ribosomal Small Subunit Biogenesis Cellular Protein Metabolic Process
Pathways		Phenylalanine and tyrosine catabolism Abnormal metabolism in phenylketonuria Metabolism of amino acids and derivatives	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs		L-Phenylalanine Tetrahydrobiopterin Norepinephrine Epinephrine Quinonoid 7,8-Tetrahydrobiopterin (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin Beta(2-Thienyl)Alanine 7,8-Dihydrobiopterin Norleucine Droxidopa
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PCBD1 QDPR RPS24	5 interactors: PAH PCBD1 PNISR STK17B TAF9
Entrez ID		5053	6229
HPRD ID		08943	03877
Ensembl ID		ENSG00000171759	ENSG00000138326
Uniprot IDs		P00439	P62847
PDB IDs		1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5PAH 6PAH	3J3A
Enriched GO Terms of Interacting Partners?		Tetrahydrobiopterin Biosynthetic Process L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Aromatic Compound Catabolic Process Pteridine-containing Compound Biosynthetic Process Aromatic Amino Acid Family Metabolic Process Pteridine-containing Compound Metabolic Process Cellular Amino Acid Catabolic Process Coenzyme Biosynthetic Process Carboxylic Acid Catabolic Process Dihydrobiopterin Metabolic Process Alpha-amino Acid Metabolic Process Catabolic Process Cofactor Metabolic Process Response To Aluminum Ion Cellular Amino Acid Metabolic Process Regulation Of Protein Homodimerization Activity Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA Response To Lead Ion Ribosomal Small Subunit Biogenesis Carboxylic Acid Metabolic Process Response To Glucagon Organic Acid Metabolic Process Cellular Response To Drug Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Protein Homotetramerization Cellular Nitrogen Compound Metabolic Process Viral Transcription Oxidation-reduction Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Nitrogen Compound Metabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Protein Tetramerization Erythrocyte Homeostasis Protein Localization To Endoplasmic Reticulum RRNA Processing Protein Heterooligomerization RRNA Metabolic Process Myeloid Cell Homeostasis Translational Termination Regulation Of Protein Binding Nuclear-transcribed MRNA Catabolic Process Liver Development MRNA Catabolic Process	L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Aromatic Amino Acid Family Metabolic Process Cellular Amino Acid Catabolic Process Carboxylic Acid Catabolic Process Alpha-amino Acid Metabolic Process Positive Regulation Of Fibroblast Apoptotic Process Tetrahydrobiopterin Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Aromatic Compound Catabolic Process Cellular Amino Acid Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Neurotransmitter Biosynthetic Process Regulation Of Protein Homodimerization Activity Catecholamine Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Neurotransmitter Metabolic Process Positive Regulation Of Response To Cytokine Stimulus Pteridine-containing Compound Biosynthetic Process Catecholamine Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Histone H3 Acetylation Pteridine-containing Compound Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Carboxylic Acid Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Homotetramerization
Tagcloud ?		ace anesthetized angiotensin ascribed b2 bradykinin cei clarify clearances converting deleterious fall gfr hemodynamic hoe indices inulin kinin kininases maintains microg neonatal newborn perindoprilat postglomerular rabbits reflected renin vasodilation	3p biogenesis blackfan comprehensive constructed dba defective definitive deformities deregulated diamond enforced erythrocyte hematopoiesis hscs insights mirna mirnas morpholino network phenotypes prediction primitive progenitor ribosome seq uniquely zebrafish
Tagcloud (Difference) ?		ace anesthetized angiotensin ascribed b2 bradykinin cei clarify clearances converting deleterious fall gfr hemodynamic hoe indices inulin kinin kininases maintains microg neonatal newborn perindoprilat postglomerular rabbits reflected renin vasodilation	3p biogenesis blackfan comprehensive constructed dba defective definitive deformities deregulated diamond enforced erythrocyte hematopoiesis hscs insights mirna mirnas morpholino network phenotypes prediction primitive progenitor ribosome seq uniquely zebrafish
Tagcloud (Intersection) ?