PCBD1 and ZNF567

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		PCBD1	ZNF567
Description		pterin-4 alpha-carbinolamine dehydratase 1	zinc finger protein 567
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Nucleus
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of DNA-templated Transcription	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process
Pathways		Phenylalanine metabolism	Generic Transcription Pathway
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)
Interacting Genes		53 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	3 interacting genes: FAM9B MAP3K20 PCBD1
Entrez ID		5092	163081
HPRD ID		00523	11728
Ensembl ID		ENSG00000166228	ENSG00000189042
Uniprot IDs		P61457	B2R956 B4E0D0 F8WEL6 Q8N184
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Zinc Ion Binding Chromatin Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Frizzled Binding Epigenetic Regulation Of Gene Expression Metal Ion Binding Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TRNA Transcription By RNA Polymerase III TRNA Transcription Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Activity RSC-type Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition	4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of Mitotic DNA Damage Checkpoint Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress GCN2-mediated Signaling Stalled Ribosome Sensor Activity Positive Regulation Of DNA Damage Checkpoint Tetrahydrobiopterin Metabolic Process Tetrahydrobiopterin Biosynthetic Process JUN Kinase Kinase Kinase Activity Negative Regulation Of Translation In Response To Stress Small Ribosomal Subunit RRNA Binding NLRP1 Inflammasome Complex Assembly Regulation Of Translation In Response To Endoplasmic Reticulum Stress Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Pteridine-containing Compound Biosynthetic Process Cellular Response To UV-B Tyrosine Metabolic Process Protein Kinase Regulator Activity Positive Regulation Of Cell Cycle Checkpoint Response To UV-B Regulation Of DNA Damage Checkpoint Regulation Of Translation In Response To Stress MAP Kinase Kinase Kinase Activity Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade P38MAPK Cascade Synaptonemal Complex Diol Metabolic Process Cellular Response To Gamma Radiation Pteridine-containing Compound Metabolic Process Canonical Inflammasome Complex Assembly Aromatic Amino Acid Metabolic Process Regulation Of Stress-activated Protein Kinase Signaling Cascade Integrated Stress Response Signaling Pyroptotic Inflammatory Response Protein Kinase Activator Activity RRNA Binding Embryonic Digit Morphogenesis Response To Gamma Radiation Limb Development JNK Cascade Amino Acid Biosynthetic Process
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