PAH and QDPR

Number of citations of the paper that reports this interaction (PubMedID 11461190)
0

Data Source:
BioGRID (two hybrid)

		PAH	QDPR
Description		phenylalanine hydroxylase	quinoid dihydropteridine reductase
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GO Annotations	Cellular Component	Cytosol	Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity Monooxygenase Activity Phenylalanine 4-monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Metal Ion Binding	6,7-dihydropteridine Reductase Activity Electron Transfer Activity Oxidoreductase Activity NADPH Binding NADH Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Biosynthetic Process Amino Acid Biosynthetic Process Aromatic Amino Acid Metabolic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Catecholamine Biosynthetic Process	Amino Acid Metabolic Process L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Metabolic Process Dihydrobiopterin Metabolic Process
Pathways		Phenylketonuria Phenylalanine metabolism	Phenylalanine metabolism
Drugs		Phenylalanine Sapropterin Norepinephrine Quinonoid 7,8-Tetrahydrobiopterin beta-2-Thienyl-L-alanine L-erythro-7,8-dihydrobiopterin D-norleucine Droxidopa	NADH 2-(N-morpholino)ethanesulfonic acid
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient	Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271)	Blood protein levels ( 30072576)
Interacting Genes		3 interacting genes: PCBD1 QDPR RPS24	5 interacting genes: ANKRD13A CASP8 KRAS PAH RXFP4
Entrez ID		5053	5860
HPRD ID		08943	02025
Ensembl ID		ENSG00000171759	ENSG00000151552
Uniprot IDs		P00439	A0A140VKA9 P09417
PDB IDs		1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5FII 5PAH 6HPO 6HYC 6N1K 6PAH	1HDR
Enriched GO Terms of Interacting Partners?		Tetrahydrobiopterin Metabolic Process Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Diol Metabolic Process Pteridine-containing Compound Metabolic Process Aromatic Amino Acid Metabolic Process Response To G1 DNA Damage Checkpoint Signaling Dihydrobiopterin Metabolic Process 6,7-dihydropteridine Reductase Activity 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine L-amino Acid Metabolic Process Apoptosome NADH Binding Alpha-amino Acid Metabolic Process Amino Acid Metabolic Process Response To DNA Damage Checkpoint Signaling Alcohol Metabolic Process L-phenylalanine Catabolic Process Regulation Of Apoptotic DNA Fragmentation Cysteine-type Endopeptidase Activator Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Erythrocyte Homeostasis Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Tyrosine Metabolic Process Small Molecule Biosynthetic Process NADPH Binding Muscle Cell Apoptotic Process Aromatic Amino Acid Family Catabolic Process Translation Initiation Factor Binding Small Ribosomal Subunit Extracellular Exosome Myeloid Cell Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress ADP Binding Cytosolic Small Ribosomal Subunit Cytosol Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Electron Transfer Activity Cellular Response To Transforming Growth Factor Beta Stimulus Heat Shock Protein Binding Amino Acid Biosynthetic Process	Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development GMP Binding Forebrain Astrocyte Development Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Negative Regulation Of Protein Localization To Endosome Death Effector Domain Binding Response To Isolation Stress Positive Regulation Of Pyroptotic Inflammatory Response Response To Anesthetic Ripoptosome Self Proteolysis Response To Cobalt Ion Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process CD95 Death-inducing Signaling Complex TRAIL-activated Apoptotic Signaling Pathway Mitochondrial Outer Membrane LRR Domain Binding Type I Pneumocyte Differentiation Response To Gravity L-phenylalanine Catabolic Process Ubiquitin-modified Protein Reader Activity Galanin Receptor Activity Positive Regulation Of Feeding Behavior Myoblast Proliferation Positive Regulation Of Macrophage Differentiation Protein-containing Complex Binding Positive Regulation Of Cellular Senescence Tyrosine Metabolic Process Negative Regulation Of Receptor Internalization
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