PCBD1 and SOWAHC

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		PCBD1	SOWAHC
Description		pterin-4 alpha-carbinolamine dehydratase 1	sosondowah ankyrin repeat domain family member C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity Identical Protein Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of DNA-templated Transcription
Pathways		Phenylalanine metabolism	RHOA GTPase cycle RHOB GTPase cycle RHOF GTPase cycle
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Schizophrenia ( 26198764) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		53 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	3 interacting genes: LIG4 PCBD1 PTPRF
Entrez ID		5092	65124
HPRD ID		00523	08643
Ensembl ID		ENSG00000166228	ENSG00000198142
Uniprot IDs		P61457	Q53LP3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Zinc Ion Binding Chromatin Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Frizzled Binding Epigenetic Regulation Of Gene Expression Metal Ion Binding Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TRNA Transcription By RNA Polymerase III TRNA Transcription Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Activity RSC-type Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition	Establishment Of Integrated Proviral Latency Establishment Of Viral Latency 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Chondroitin Sulfate Proteoglycan Binding DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DNA Ligase Activity DN2 Thymocyte Differentiation Negative Regulation Of Receptor Binding Nucleotide-excision Repair, DNA Gap Filling DNA-dependent Protein Kinase-DNA Ligase 4 Complex Tetrahydrobiopterin Biosynthetic Process Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Tetrahydrobiopterin Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Lymphoid Progenitor Cell Differentiation AMP Binding Pteridine-containing Compound Biosynthetic Process Cellular Response To Lithium Ion Tyrosine Metabolic Process Response To Lithium Ion Transmembrane Receptor Protein Tyrosine Phosphatase Activity V(D)J Recombination Peptidyl-tyrosine Dephosphorylation Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Synaptic Membrane Adhesion Somatic Diversification Of Immunoglobulins Involved In Immune Response Response To X-ray Diol Metabolic Process Neuron Projection Regeneration Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Negative Regulation Of Protein Binding Pteridine-containing Compound Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Aromatic Amino Acid Metabolic Process Somatic Cell DNA Recombination T Cell Differentiation In Thymus Somatic Diversification Of Immunoglobulins
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?