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PCBD1 and POLR3A
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
PCBD1
POLR3A
Gene Name
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Vesicular Exosome
Nucleoplasm
DNA-directed RNA Polymerase III Complex
Cytosol
Membrane
Molecular Function
Transcription Coactivator Activity
Phenylalanine 4-monooxygenase Activity
Protein Binding
4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity
Identical Protein Binding
RNA Polymerase III Activity
DNA Binding
Chromatin Binding
DNA-directed RNA Polymerase Activity
Zinc Ion Binding
Ribonucleoside Binding
Biological Process
Transcription, DNA-templated
L-phenylalanine Catabolic Process
Tetrahydrobiopterin Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Protein Homodimerization Activity
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Homotetramerization
Protein Heterooligomerization
Oxidation-reduction Process
Transcription, DNA-templated
Transcription From RNA Polymerase III Promoter
Transcription Elongation From RNA Polymerase III Promoter
Termination Of RNA Polymerase III Transcription
Gene Expression
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-beta Production
Innate Immune Response
Defense Response To Virus
Pathways
Phenylalanine and tyrosine catabolism
Metabolism of amino acids and derivatives
RNA Polymerase III Transcription Termination
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase III Abortive And Retractive Initiation
Cytosolic sensors of pathogen-associated DNA
RNA Polymerase III Chain Elongation
RNA Polymerase III Transcription Initiation From Type 2 Promoter
Innate Immune System
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
49 interactors:
ACIN1
APP
BRD7
CACNA1C
CALCOCO1
CDK5RAP2
CEBPZ
DENND4A
DIP2C
DVL2
DYRK1B
EHMT1
FXR2
GORASP2
GTF3C3
HES4
HNF1A
HNF1B
HNF4A
KLF13
LNX1
MIS18BP1
NFKB1
NIF3L1
NUDT18
PAH
PAPOLG
PCBD2
POLR3A
RBL2
RPS24
SAP30
SCMH1
SMARCD1
SOWAHC
SUPT5H
TFF3
TIMELESS
TRIM5
WDYHV1
WWP1
ZBTB25
ZNF195
ZNF202
ZNF23
ZNF263
ZNF451
ZNF567
ZNF714
6 interactors:
EWSR1
IKBKG
NEDD4
PCBD1
PKP2
POLR3E
Entrez ID
5092
11128
HPRD ID
00523
17879
Ensembl ID
ENSG00000166228
ENSG00000148606
Uniprot IDs
P61457
O14802
PDB IDs
Enriched GO Terms of Interacting Partners
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RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
RNA Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cellular Nitrogen Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Gene Expression
Heterocycle Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Biosynthetic Process
Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Metabolic Process
Chromatin Remodeling
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Chromatin Organization
Insulin Secretion
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Chromosome Organization
Chromatin Modification
Endocrine Pancreas Development
Regulation Of Cellular Process
Peptide Hormone Secretion
Peptide Secretion
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Cellular Process
Positive Regulation Of DNA-templated Transcription, Initiation
Hormone Secretion
Regulation Of Sodium Ion Transport
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Transmission Of Virus
Development Involved In Symbiotic Interaction
Regulation Of Type I Interferon Production
Adherens Junction Maintenance
Intracellular Receptor Signaling Pathway
Transcription, DNA-templated
Maintenance Of Organ Identity
Heart Morphogenesis
RNA Biosynthetic Process
Intermediate Filament Bundle Assembly
Progesterone Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Response To Virus
Bundle Of His Cell To Purkinje Myocyte Communication
Regulation Of Membrane Potential
Glucocorticoid Receptor Signaling Pathway
Desmosome Assembly
Tetrahydrobiopterin Biosynthetic Process
Regulation Of Tight Junction Assembly
Immune Response
Protein Targeting To Lysosome
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
L-phenylalanine Catabolic Process
Negative Regulation Of Sodium Ion Transport
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Desmosome Organization
Positive Regulation Of Cytokine Production
L-phenylalanine Metabolic Process
Protein Localization To Lysosome
Cell Communication By Electrical Coupling
RNA Metabolic Process
Termination Of RNA Polymerase III Transcription
Transcription Elongation From RNA Polymerase III Promoter
Cell-cell Signaling Involved In Cardiac Conduction
Intermediate Filament Organization
Regulation Of Protein Homodimerization Activity
Receptor Catabolic Process
Ventricular Cardiac Muscle Cell Action Potential
Gene Expression
Protein Targeting To Vacuole
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Heart Rate By Cardiac Conduction
Cellular Macromolecule Biosynthetic Process
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Gap Junction Assembly
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Establishment Of Protein Localization To Vacuole
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