PAH

Gene Name		phenylalanine hydroxylase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Phenylalanine 4-monooxygenase Activity Iron Ion Binding Amino Acid Binding
	Biological Process	L-phenylalanine Catabolic Process Cellular Amino Acid Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Neurotransmitter Biosynthetic Process Catecholamine Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Phenylalanine and tyrosine catabolism Abnormal metabolism in phenylketonuria Metabolism of amino acids and derivatives
Drugs		L-Phenylalanine Tetrahydrobiopterin Norepinephrine Epinephrine Quinonoid 7,8-Tetrahydrobiopterin (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin Beta(2-Thienyl)Alanine 7,8-Dihydrobiopterin Norleucine Droxidopa
Diseases
GWAS
Protein-protein Interactions		3 interactors: PCBD1 QDPR RPS24
Entrez ID		5053
HPRD ID		08943
Ensembl ID		ENSG00000171759
Uniprot IDs		P00439
PDB IDs		1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5PAH 6PAH
Enriched GO Terms of Interacting Partners?		Tetrahydrobiopterin Biosynthetic Process L-phenylalanine Catabolic Process L-phenylalanine Metabolic Process Aromatic Compound Catabolic Process Pteridine-containing Compound Biosynthetic Process Aromatic Amino Acid Family Metabolic Process Pteridine-containing Compound Metabolic Process Cellular Amino Acid Catabolic Process Coenzyme Biosynthetic Process Carboxylic Acid Catabolic Process Dihydrobiopterin Metabolic Process Alpha-amino Acid Metabolic Process Catabolic Process Cofactor Metabolic Process Response To Aluminum Ion Cellular Amino Acid Metabolic Process Regulation Of Protein Homodimerization Activity Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA Response To Lead Ion Ribosomal Small Subunit Biogenesis Carboxylic Acid Metabolic Process Response To Glucagon Organic Acid Metabolic Process Cellular Response To Drug Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Protein Homotetramerization Cellular Nitrogen Compound Metabolic Process Viral Transcription Oxidation-reduction Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Nitrogen Compound Metabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Protein Tetramerization Erythrocyte Homeostasis Protein Localization To Endoplasmic Reticulum RRNA Processing Protein Heterooligomerization RRNA Metabolic Process Myeloid Cell Homeostasis Translational Termination Regulation Of Protein Binding Nuclear-transcribed MRNA Catabolic Process Liver Development MRNA Catabolic Process
Tagcloud ?		ace anesthetized angiotensin ascribed b2 bradykinin cei clarify clearances converting deleterious fall gfr hemodynamic hoe indices inulin kinin kininases maintains microg neonatal newborn perindoprilat postglomerular rabbits reflected renin vasodilation