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PCBD1 and CDK5RAP2
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
PCBD1
CDK5RAP2
Description
pterin-4 alpha-carbinolamine dehydratase 1
CDK5 regulatory subunit associated protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Pericentriolar Material
Spindle Pole
Gamma-tubulin Ring Complex
Cytoplasm
Golgi Apparatus
Centrosome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Microtubule
Cell Junction
Microtubule Plus-end
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Mitotic Spindle Pole
Molecular Function
Transcription Coactivator Activity
Phenylalanine 4-monooxygenase Activity
Protein Binding
4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity
Lyase Activity
Identical Protein Binding
Transcription Cis-regulatory Region Binding
Protein Binding
Calmodulin Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Gamma-tubulin Binding
Protein-containing Complex Binding
Biological Process
Tetrahydrobiopterin Biosynthetic Process
Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine
Positive Regulation Of DNA-templated Transcription
Establishment Of Mitotic Spindle Orientation
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Chromosome Segregation
Centrosome Cycle
Centriole Replication
Brain Development
Neurogenesis
Microtubule Organizing Center Organization
Positive Regulation Of Microtubule Polymerization
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Centriole Replication
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways
Phenylalanine metabolism
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
L-erythro-7,8-dihydrobiopterin
Diseases
Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
Primary microcephaly (MCPH)
GWAS
Blood protein levels (
30072576
)
Chronotype (
30696823
)
Immature fraction of reticulocytes (
27863252
)
Microalbuminuria (
26631737
)
Obesity-related traits (
23251661
)
Asthma (
27611488
)
Height (
28552196
)
Photic sneeze reflex (
27182965
)
Response to statin therapy (
20339536
)
Rheumatoid arthritis (
24782177
)
Interacting Genes
53 interacting genes:
ACIN1
APP
BRD7
CACNA1C
CALCOCO1
CDK5RAP2
CEBPZ
DENND4A
DIP2C
DVL2
DYRK1B
EHMT1
FXR2
GORASP2
GTF3C3
HES4
HNF1A
HNF4A
KANK2
KLF13
LNX1
MIS18BP1
NFKB1
NIF3L1
NTAQ1
NUDT18
PAH
PAPOLG
PCBD2
PICK1
POLR3A
PSMA1
RBL2
RPS24
SAP30
SCMH1
SDCBP
SMARCD1
SOWAHC
SUPT5H
TFF3
TIMELESS
TRIM5
WWP1
ZBTB25
ZNF195
ZNF202
ZNF23
ZNF263
ZNF451
ZNF567
ZNF688
ZNF714
26 interacting genes:
ABCA2
CDK5
CDK5R1
CLIP4
CRMP1
EEF1G
ERG28
FBXO25
HAP1
KAT5
LRRK1
LUC7L2
MAGEH1
MAPRE1
NEFL
PCBD1
PTN
RBM48
REPS2
SENP2
STARD9
STK36
TBC1D4
TRIM37
TSNAX
ZPR1
Entrez ID
5092
55755
HPRD ID
00523
09740
Ensembl ID
ENSG00000166228
ENSG00000136861
Uniprot IDs
P61457
A0A0A0MRG9
A0A8I5KXG0
A0A8I5QKL1
B3KVI2
B9EG74
Q96SN8
PDB IDs
6X0V
8RX1
9G3Y
9G3Z
9G40
9H9P
Enriched GO Terms of Interacting Partners
?
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Nucleus
DNA Binding
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Zinc Ion Binding
Chromatin Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription Cis-regulatory Region Binding
Frizzled Binding
Epigenetic Regulation Of Gene Expression
Metal Ion Binding
Positive Regulation Of Biosynthetic Process
Transcription Coactivator Activity
Nucleoplasm
Positive Regulation Of Metabolic Process
Chromatin
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
TRNA Transcription By RNA Polymerase III
TRNA Transcription
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Macromolecule Metabolic Process
Transcription Coregulator Activity
Regulation Of Mitotic Cell Cycle
DNA-binding Transcription Factor Activity
RSC-type Complex
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G1/S Phase Transition
Microtubule Cytoskeleton Organization
Growth Cone
Microtubule-based Process
Protein Kinase 5 Complex
Cytoskeleton Organization
Cerebellum Development
Establishment Of Organelle Localization
Perikaryon
Negative Regulation Of Motor Neuron Apoptotic Process
Hippocampus Development
Cell Projection Organization
ESC/E(Z) Complex
Regulation Of Motor Neuron Apoptotic Process
Neuromuscular Junction
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Axon
Layer Formation In Cerebral Cortex
Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Neuron Projection Development
Cell Projection
Regulation Of Nervous System Development
Retrograde Axonal Transport
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Microtubule Plus-end Binding
Microtubule Plus-end
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Neuron Apoptotic Process
Organelle Localization
Regulation Of Microtubule-based Process
Regulation Of Intracellular Transport
Neuron Projection Regeneration
Diol Metabolic Process
Neuron Projection Development
Regulation Of Cellular Component Organization
Ionotropic Glutamate Receptor Binding
Spinal Cord Development
Endopeptidase Regulator Activity
Regulation Of Cellular Localization
Regulation Of Protein Targeting To Membrane
Regulation Of Synapse Organization
Organelle Organization
Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Regulation Of Postsynapse Organization
Positive Regulation Of Presynaptic Cytosolic Calcium Concentration
Positive Regulation Of Microtubule Polymerization
DNA Endoreduplication
Pre-mRNA Catabolic Process
Positive Regulation Of Neurotrophin Production
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Tagcloud (Intersection)
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