PCBD1 and MIS18BP1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		PCBD1	MIS18BP1
Description		pterin-4 alpha-carbinolamine dehydratase 1	MIS18 binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome CENP-A Recruiting Complex
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity Identical Protein Binding	DNA Binding Protein Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of DNA-templated Transcription	CENP-A Containing Chromatin Assembly Cell Division Pericentric Heterochromatin Organization
Pathways		Phenylalanine metabolism	Deposition of new CENPA-containing nucleosomes at the centromere Cyclin A/B1/B2 associated events during G2/M transition
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Shoulder impingement ( 33482370) Sjögren's syndrome ( 28076899)
Interacting Genes		53 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	6 interacting genes: CDK1 FBXO7 MIS18A OIP5 PCBD1 SP1
Entrez ID		5092	55320
HPRD ID		00523	12629
Ensembl ID		ENSG00000166228	ENSG00000129534
Uniprot IDs		P61457	Q6P0N0
PDB IDs			1WGX 8S31
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Zinc Ion Binding Chromatin Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Frizzled Binding Epigenetic Regulation Of Gene Expression Metal Ion Binding Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TRNA Transcription By RNA Polymerase III TRNA Transcription Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Activity RSC-type Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition	Pericentric Heterochromatin Organization CENP-A Recruiting Complex CENP-A Containing Chromatin Assembly Protein Localization To Chromosome, Centromeric Region Nucleoplasm Protein Localization To Chromosome Pronuclear Fusion Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cell Division 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Response To Wortmannin Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Chromatin Remodeling Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Heterochromatin Formation Chromosome Segregation Lewy Body Core Regulation Of Schwann Cell Differentiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Identical Protein Binding Chromosome, Centromeric Region Negative Regulation Of Gene Expression, Epigenetic Regulation Of Metabolic Process Thymidine Biosynthetic Process Chromatin Organization Golgi Disassembly Nuclear DNA Replication Histone Kinase Activity Cellular Response To Zinc Ion Starvation Negative Regulation Of Mitotic Cell Cycle Thymidine Metabolic Process Tetrahydrobiopterin Biosynthetic Process Negative Regulation Of Cell Cycle Phase Transition Nucleus Positive Regulation Of Mitotic Sister Chromatid Segregation Tetrahydrobiopterin Metabolic Process
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