PCBD1 and ZBTB25

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PCBD1	ZBTB25
Gene Name		pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	zinc finger and BTB domain containing 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Homodimerization Activity Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Homotetramerization Protein Heterooligomerization Oxidation-reduction Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression
Pathways		Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		49 interactors: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NUDT18 PAH PAPOLG PCBD2 POLR3A RBL2 RPS24 SAP30 SCMH1 SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WDYHV1 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF714	20 interactors: APIP COIL CYP2J2 DDIT3 FCGR3A HCLS1 KCTD1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 TNIP1 TRAF2 TSSK3 ZBTB1
Entrez ID		5092	7597
HPRD ID		00523	01926
Ensembl ID		ENSG00000166228
Uniprot IDs		P61457	P24278
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Metabolic Process Chromatin Remodeling Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Chromatin Organization Insulin Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Endocrine Pancreas Development Regulation Of Cellular Process Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Cellular Process Positive Regulation Of DNA-templated Transcription, Initiation Hormone Secretion	Regulation Of Phosphorylation Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Signaling Protein Homooligomerization MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Immune System Process MRNA Transcription Toll-like Receptor Signaling Pathway Protein Complex Assembly Regulation Of Transcription, DNA-templated Regulation Of Protein Homodimerization Activity Positive Regulation Of Immune Response Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Oligomerization Regulation Of Immune System Process Regulation Of Gene Expression Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Innate Immune Response Negative Regulation Of Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Pro-T Cell Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Cell Death Regulation Of Innate Immune Response Regulation Of Binding Positive Regulation Of Apoptotic Process
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