PCBD1 and TIMELESS

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PCBD1	TIMELESS
Gene Name		pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	timeless circadian clock
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	Nuclear Chromatin Nucleus Nucleolus Microtubule Cytoskeleton
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Protein Homodimerization Activity Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Homotetramerization Protein Heterooligomerization Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Morphogenesis Of An Epithelium Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Circadian Rhythm Detection Of Abiotic Stimulus Response To Abiotic Stimulus Lung Development Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Branching Morphogenesis Of An Epithelial Tube Cell Division
Pathways		Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		49 interactors: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NUDT18 PAH PAPOLG PCBD2 POLR3A RBL2 RPS24 SAP30 SCMH1 SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WDYHV1 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF714	9 interactors: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1
Entrez ID		5092	8914
HPRD ID		00523	04864
Ensembl ID		ENSG00000166228	ENSG00000111602
Uniprot IDs		P61457	Q9UNS1
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Gene Expression Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Metabolic Process Chromatin Remodeling Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Chromatin Organization Insulin Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Endocrine Pancreas Development Regulation Of Cellular Process Peptide Hormone Secretion Peptide Secretion Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Cellular Process Positive Regulation Of DNA-templated Transcription, Initiation Hormone Secretion	Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Response To Light Stimulus Photoperiodism Entrainment Of Circadian Clock Blue Light Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Radiation Circadian Rhythm Response To Blue Light Circadian Regulation Of Translation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process DNA Damage Induced Protein Phosphorylation Rhythmic Process Cellular Response To Light Stimulus Protein-chromophore Linkage Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Histone H3 Deacetylation RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gluconeogenesis Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Histone Deacetylation Hexose Biosynthetic Process Protein Deacetylation Histone Modification RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription, Termination
Tagcloud ?			ancestral anthropogenic arthropod calanus californicus circadian clock clockwork copepod copepods crustacean cryptochrome daphnia doubletime finmarchicus inputs intertidal orange pacemaker publicly pulex rhythms shaggy stressor stressors suite supernumerary tigriopus vrille
Tagcloud (Difference) ?			ancestral anthropogenic arthropod calanus californicus circadian clock clockwork copepod copepods crustacean cryptochrome daphnia doubletime finmarchicus inputs intertidal orange pacemaker publicly pulex rhythms shaggy stressor stressors suite supernumerary tigriopus vrille
Tagcloud (Intersection) ?