LCE1B and KRTAP12-4

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE1B	KRTAP12-4
Description		late cornified envelope 1B	keratin associated protein 12-4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol Intermediate Filament
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Epidermis Development Keratinization
Pathways		Formation of the cornified envelope	Keratinization
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		82 interacting genes: ADAMTSL4 ALPP BEND5 CATSPER1 CHIC2 CYSRT1 FBLN1 FUCA2 GRN HOXA1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MDFI MEOX2 NAPSA NBPF19 NOTCH2NLA NUFIP2 OTX1 P4HB RGS17 RGS20 RNF4 SMCP SPRY1 SPRY2 SPRY3 TGM1 TRIM42 VASN	51 interacting genes: AQP1 ARID5A ATXN1 ATXN2L CH25H CYSRT1 FBXO34 GPRIN2 HMGB4 HOXA1 IQUB KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP6-2 KRTAP8-1 LASP1 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2C LCE3A LCE3D LCE4A LCE5A MEOX2 MGAT5B NBPF19 NOTCH2NLA NR4A3 OLIG2 OTX1 PIH1D2 POU4F2 RBPMS RERE SMCP SPMIP9 SSC4D TEKT5 TRIP13 VENTX
Entrez ID		353132	386684
HPRD ID		17259	11200
Ensembl ID		ENSG00000196734	ENSG00000212933
Uniprot IDs		Q5T7P3	P60329
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Cytosol Protein Binding Identical Protein Binding Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Ras Protein Signal Transduction Microtubule End Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Lens Fiber Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Keratinization Epidermis Development Intermediate Filament Tissue Development Identical Protein Binding Keratin Filament Protein Binding Sequence-specific DNA Binding Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility
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