LCE1B and BEND5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LCE1B	BEND5
Description		late cornified envelope 1B	BEN domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Golgi Apparatus
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding Protein Binding
	Biological Process	Epidermis Development Keratinization	Negative Regulation Of DNA-templated Transcription
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		82 interacting genes: ADAMTSL4 ALPP BEND5 CATSPER1 CHIC2 CYSRT1 FBLN1 FUCA2 GRN HOXA1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MDFI MEOX2 NAPSA NBPF19 NOTCH2NLA NUFIP2 OTX1 P4HB RGS17 RGS20 RNF4 SMCP SPRY1 SPRY2 SPRY3 TGM1 TRIM42 VASN	31 interacting genes: APP BUD31 CFTR CTNNBIP1 DDR1 EIF3D ERBB3 FAM161A FXR1 GFI1B GORASP2 GRAP2 HOXA1 LCE1B LMO3 NTAQ1 PIMREG PRKAB2 PTGR2 RTP5 SMARCD1 TSC1 TSPOAP1 UBE2I USP2 USP20 USP7 VPS25 ZGPAT ZNF417 ZNF688
Entrez ID		353132	79656
HPRD ID		17259	07756
Ensembl ID		ENSG00000196734	ENSG00000162373
Uniprot IDs		Q5T7P3	A0A0S2Z5N0 Q7L4P6
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Cytosol Protein Binding Identical Protein Binding Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Ras Protein Signal Transduction Microtubule End Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Lens Fiber Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Long-term Synaptic Potentiation Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity
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