TRADD and TNFRSF10A

Number of citations of the paper that reports this interaction (PubMedID 9430227)
0

Data Source:
HPRD (in vivo)

		TRADD	TNFRSF10A
Description		TNFRSF1A associated via death domain	TNF receptor superfamily member 10a
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GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Death-inducing Signaling Complex Receptor Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Membrane Raft
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Kinase Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Molecular Adaptor Activity Death Domain Binding	Protease Binding Death Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding TRAIL Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Inflammatory Response Positive Regulation Of Hair Follicle Development Cellular Response To Tumor Necrosis Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Dimerization of procaspase-8 TNF signaling Defective RIPK1-mediated regulated necrosis	Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625) Central serous retinopathy ( 31872073) Early age-related macular degeneration ( 32843070)
Interacting Genes		24 interacting genes: APBB2 BCL10 BIRC2 CNTRL DAPK1 FADD FAS HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TMC8 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP	15 interacting genes: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD
Entrez ID		8717	8797
HPRD ID		04610	04679
Ensembl ID		ENSG00000102871	ENSG00000104689
Uniprot IDs		Q15628	O00220
PDB IDs		1F2H 1F3V 5XME 6AC0 7CSQ	5CIR
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Cell Death Programmed Cell Death Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Death Receptor Activity Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Death-inducing Signaling Complex Tumor Necrosis Factor Binding Negative Regulation Of Apoptotic Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Lymphocyte Apoptotic Process Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Activity Thioesterase Binding CD40 Receptor Complex Neuron Apoptotic Process Leukocyte Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Signaling Receptor Activity Negative Regulation Of Necroptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Necrotic Cell Death Negative Regulation Of Programmed Necrotic Cell Death	Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Death Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process TRAIL Binding Positive Regulation Of Programmed Cell Death Ripoptosome Positive Regulation Of Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Necroptotic Process Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Positive Regulation Of Defense Response Positive Regulation Of Myeloid Cell Differentiation Death Domain Binding Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Regulation Of Myeloid Leukocyte Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Death Effector Domain Binding Regulation Of Programmed Necrotic Cell Death
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