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TRADD and PPP2R1A
Number of citations of the paper that reports this interaction (PubMedID
17540176
)
58
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
TRADD
PPP2R1A
Description
TNFRSF1A associated via death domain
protein phosphatase 2 scaffold subunit Aalpha
Image
GO Annotations
Cellular Component
Tumor Necrosis Factor Receptor Superfamily Complex
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Death-inducing Signaling Complex
Receptor Complex
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Dendrite
Cell Projection
Neuron Projection
Neuronal Cell Body
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
Glutamatergic Synapse
INTAC Complex
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Kinase Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Identical Protein Binding
Molecular Adaptor Activity
Death Domain Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Heterodimerization Activity
Protein Antigen Binding
Biological Process
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Canonical NF-kappaB Signal Transduction
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Cell Migration
Tumor Necrosis Factor-mediated Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Inflammatory Response
Positive Regulation Of Hair Follicle Development
Cellular Response To Tumor Necrosis Factor
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Chromosome Segregation
Female Meiotic Nuclear Division
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Spindle Assembly
Meiotic Spindle Elongation
Mitotic Sister Chromatid Separation
Meiotic Sister Chromatid Cohesion, Centromeric
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein-containing Complex Assembly
RNA Polymerase II Transcription Initiation Surveillance
Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
TNF signaling
Defective RIPK1-mediated regulated necrosis
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Initiation of Nuclear Envelope (NE) Reformation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
AURKA Activation by TPX2
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Interacting Genes
24 interacting genes:
APBB2
BCL10
BIRC2
CNTRL
DAPK1
FADD
FAS
HIPK2
KRT14
KRT18
NGFR
PPP2R1A
RIPK1
STAT1
TMC8
TNFRSF10A
TNFRSF10B
TNFRSF1A
TNFRSF21
TNFRSF25
TRAF1
TRAF2
TRAF3
TRPC4AP
59 interacting genes:
AIMP2
AKT1
AMOTL2
ARIH2
ATM
CARD11
CARHSP1
CDC42
CDK1
CSDC2
CSNK2B
DAPK1
DELEC1
DUX4
EEF2
ESR1
FBXO43
GNA12
GOLGA6A
GOLGA8F
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
LINC01554
MAP3K7
MAPK6
MCM3
OGT
PARK7
PLAAT3
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP2R5B
PPP4C
PPP5C
PRDX1
PRDX2
PTPA
RAB11A
RAB18
RAB7A
RAP1A
RORC
SGO1
SGO2
SLC25A21-AS1
SLC6A2
SMAD2
SMAD3
STRN
STRN3
SUMO2
TAB1
TRADD
ZFYVE9
Entrez ID
8717
5518
HPRD ID
04610
16184
Ensembl ID
ENSG00000102871
ENSG00000105568
Uniprot IDs
Q15628
A8K7B7
B3KQV6
P30153
PDB IDs
1F2H
1F3V
5XME
6AC0
7CSQ
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
4LAC
5W0W
6IUR
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
Enriched GO Terms of Interacting Partners
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Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Cell Death
Programmed Cell Death
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of Canonical NF-kappaB Signal Transduction
Cytokine-mediated Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Tumor Necrosis Factor Receptor Binding
Cellular Response To Mechanical Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Signaling Adaptor Activity
Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Death Receptor Activity
Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Death-inducing Signaling Complex
Tumor Necrosis Factor Binding
Negative Regulation Of Apoptotic Process
Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Negative Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Lymphocyte Apoptotic Process
Necroptotic Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Tumor Necrosis Factor Receptor Activity
Thioesterase Binding
CD40 Receptor Complex
Neuron Apoptotic Process
Leukocyte Apoptotic Process
Regulation Of Cell Communication
Regulation Of Signaling
Signaling Receptor Activity
Negative Regulation Of Necroptotic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Programmed Necrotic Cell Death
Negative Regulation Of Programmed Necrotic Cell Death
Protein Phosphatase Type 2A Complex
Intracellular Signal Transduction
Intracellular Signaling Cassette
Cytosol
Protein Phosphatase 2A Binding
Cytoplasm
Protein Phosphatase Regulator Activity
Signal Transduction
Peroxiredoxin Activity
Cellular Response To Oxygen-containing Compound
Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Glutamatergic Synapse
Response To Oxidative Stress
G Protein Activity
Positive Regulation Of Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein-containing Complex
Regulation Of Cell Communication
Regulation Of Signaling
Response To Growth Factor
Cellular Response To Nerve Growth Factor Stimulus
Tau Protein Binding
Response To Nerve Growth Factor
Removal Of Superoxide Radicals
Response To Reactive Oxygen Species
Positive Regulation Of Cell Communication
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signaling
Kinase Binding
Positive Regulation Of Intracellular Signal Transduction
Cell Population Proliferation
Regulation Of Programmed Cell Death
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Protein-containing Complex Binding
GTP Binding
Protein Phosphatase Activator Activity
Phosphatase Binding
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
FAR/SIN/STRIPAK Complex
Regulation Of Protein Catabolic Process
Cellular Response To Growth Factor Stimulus
Peptidyl-threonine Phosphorylation
Calmodulin Binding
Protein Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Localization
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