TRADD and TNFRSF21

Number of citations of the paper that reports this interaction (PMID 9714541)
23

Data Source:
HPRD (in vivo)

		TRADD	TNFRSF21
Gene Name		TNFRSF1A-associated via death domain	tumor necrosis factor receptor superfamily, member 21
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Death-inducing Signaling Complex Receptor Complex Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane Axon Intrinsic Component Of Plasma Membrane
	Molecular Function	Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Protein Complex Binding Identical Protein Binding Binding, Bridging Death Domain Binding	Protein Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Positive Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	B Cell Apoptotic Process Adaptive Immune Response Apoptotic Process Humoral Immune Response Negative Regulation Of B Cell Proliferation Negative Regulation Of Myelination Negative Regulation Of T Cell Proliferation Myelination Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Oligodendrocyte Differentiation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Cellular Response To Tumor Necrosis Factor Oligodendrocyte Apoptotic Process Negative Regulation Of Interleukin-5 Secretion Negative Regulation Of Interleukin-13 Secretion Negative Regulation Of Interleukin-10 Secretion
Pathways		Regulation by c-FLIP Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Panic disorder ( 19165232)
Protein-Protein Interactions		24 interactors: BCL10 BIRC2 CNTRL DAPK1 FADD FAS GFRA1 HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP	6 interactors: CLIP3 MATR3 NSD1 STX11 TRADD WASH2P
Entrez ID		8717	27242
HPRD ID		04610	05759
Ensembl ID			ENSG00000146072
Uniprot IDs		B3KQZ9 Q15628	O75509
PDB IDs		1F2H 1F3V	2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Tumor Necrosis Factor Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Peptidase Activity Cell Surface Receptor Signaling Pathway Regulation Of Endopeptidase Activity Cellular Response To Cytokine Stimulus Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Response To Cytokine Programmed Necrotic Cell Death Necrotic Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Organic Substance Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Necroptotic Signaling Pathway Zymogen Activation Negative Regulation Of Apoptotic Process Cellular Response To Organic Substance Signal Transduction Negative Regulation Of Programmed Cell Death Response To Mechanical Stimulus Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Necroptotic Process Signaling Cellular Response To Mechanical Stimulus Cell Communication Response To Abiotic Stimulus	Peptidyl-L-cysteine S-palmitoylation Neutrophil Degranulation Cytotoxic T Cell Degranulation Chaperone-mediated Protein Transport Neutrophil Activation Involved In Immune Response Regulation Of Protein Complex Assembly Histone H3-K36 Methylation Natural Killer Cell Degranulation Positive Regulation Of Hair Follicle Development Synaptic Vesicle Fusion To Presynaptic Membrane T Cell Mediated Cytotoxicity Negative Regulation Of Microtubule Polymerization Histone H4-K20 Methylation Regulation Of Hair Follicle Development Regulation Of Cytoskeleton Organization Neutrophil Mediated Immunity Neutrophil Activation Regulation Of Hair Cycle Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Natural Killer Cell Activation Involved In Immune Response Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Plasma Membrane Natural Killer Cell Mediated Immunity Membrane Biogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Microtubule Polymerization Protein Palmitoylation Positive Regulation Of Cell Death Positive Regulation Of Epidermis Development T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity
Tagcloud ?		adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit	87mg ags alteration arrayed bad bcl2 bcl2l11 bfar bnip3l casp7 cidea cideb combat endows exceptions irrelevant oct4 oct4b1 pluripotent sirnas spliced stream tenfold tp73 traf3 uncovering
Tagcloud (Difference) ?		adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit	87mg ags alteration arrayed bad bcl2 bcl2l11 bfar bnip3l casp7 cidea cideb combat endows exceptions irrelevant oct4 oct4b1 pluripotent sirnas spliced stream tenfold tp73 traf3 uncovering
Tagcloud (Intersection) ?